161878-70-2Relevant academic research and scientific papers
The Synthesis and Thymidylate Synthase Inhibitory Activity of L-γ-L-Linked Dipeptide and L-γ-Amide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid (ICI 198583)
Bisset, Graham M. F.,Bavetsias, Vassilios,Thornton, Timothy J.,Pawelczak, Krzysztof,Calvert, A. Hilary,et al.
, p. 3294 - 3302 (2007/10/02)
Sixteen γ-linked dipeptide and four L-Glu-γ-amide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) have beensynthesized and evaluated as inhibitors of thymidylate synthase (TS).Z-blocked L-Glu-γ-L-linked dipepti
