1619232-16-4Relevant academic research and scientific papers
Modification of the anticestodal drug 5-chloro-N-(2-chloro-4-nitrophenyl)- 2-hydroxybenzamide with a view to improve its biological effect
Galkina,Chubukaeva,Bakhtiyarova,Galkin,Cherkasov,Islamov,Kataeva
, p. 800 - 804 (2014)
Reactions of 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, the active substance of the drug Niclosamide (Phenasal), with higher amines (dodecan-1-amine, hexadecan-1-amine) and 1-(2-aminoethyl)-piperazine lead to the formation of the corresponding water-soluble ammonium salts with retention of pharmacophoric groups responsible for the antihelminthic effect, whereas no nucleophilic aromatic substitution of chlorine is observed. The product structure was determined by X-ray analysis.
