1619233-32-7 Usage
Uses
Used in Pharmaceutical Industry:
(S)-4-amino-2,6-dimethylhept-1-en-3-one trifluoroacetate is used as a reagent for the synthesis of peptide-based proteasome inhibitors. It plays a crucial role in the development of these inhibitors, which are essential for the treatment of various diseases, including cancer.
Used in Cancer Treatment:
(S)-4-amino-2,6-dimethylhept-1-en-3-one trifluoroacetate is used as an impurity in carfilzomib (C183460), a second-generation proteasome inhibitor. Carfilzomib is utilized as a treatment for relapsed and refractory multiple myeloma, a type of blood cancer. The compound's presence in carfilzomib contributes to the drug's effectiveness in targeting and inhibiting the proteasome, a cellular enzyme involved in the degradation of proteins.
Check Digit Verification of cas no
The CAS Registry Mumber 1619233-32-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,1,9,2,3 and 3 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1619233-32:
(9*1)+(8*6)+(7*1)+(6*9)+(5*2)+(4*3)+(3*3)+(2*3)+(1*2)=157
157 % 10 = 7
So 1619233-32-7 is a valid CAS Registry Number.
1619233-32-7Relevant academic research and scientific papers
Exploring dual electrophiles in peptide-based proteasome inhibitors: Carbonyls and epoxides
Xin, Bo-Tao,De Bruin, Gerjan,Verdoes, Martijn,Filippov, Dmitri V.,Van Der Marel, Gijs A.,Overkleeft, Herman S.
, p. 5710 - 5718 (2014/07/22)
Peptide epoxyketones are potent and selective proteasome inhibitors. Selectivity is governed by the epoxyketone dual electrophilic warhead, which reacts with the N-terminal threonine 1,2-amino alcohol uniquely present in proteasome active sites. We studied a series of C-terminally modified oligopeptides featuring adjacent electrophiles based on the epoxyketone warhead. We found that the carbonyl moiety in the natural warhead is essential, but that the adjacent epoxide can be replaced by a carbonyl, though with considerable loss of activity. the Partner Organisations 2014.
