1619266-91-9

Upstream product

• 912545-09-6 2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)benzoic acid 
• 2450-71-7 Propargylamine 

Downstream Products

• 1351815-44-5 [2,4-is(benzyloxy)-5-isopropenylphenyl]-[5-(hydroxymethyl)-1,3-dihydroisoindol-2-yl]methanone 
• 1619266-92-0 [2,4-bis(benzyloxy)-5-isopropenylphenyl]-[5-(methanesulfonyloxymethyl)-1,3-dihydroisoindol-2-yl]methanone 
• 1019890-18-6 2-(2,4-bis-benzyloxy-5-isopropenylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone 
• 1019890-32-4 2,4-Bis(benzyloxy)-5-isopropenyl-N,N-dipropargylbenzamide 

Relevant academic research and scientific papers

Alternate synthesis of HSP90 inhibitor AT13387

AT13387 is a novel HSP90 inhibitor, and it is currently used in clinical trials for the treatment of refractory gastrointestinal stromal tumors (GIST). In this article, two synthetic routes are described for synthesizing the title compound via [2 + 2 + 2]