16194-06-2Relevant articles and documents
Use of the vinyloxycarbonyl group for amino protection in peptide synthesis
Olofson,Yamamoto,Wancowicz
, p. 1563 - 1566 (1977)
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Gezielte Synthese von Peptiden aus α-Aminosaeureestern an Metallzentren
Beck, Wolfgang,Kraemer, Roland
, p. 1492 - 1493 (2007/10/02)
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STUDIES OF BITTER PEPTIDES FROM CASEIN HYDROLYZATE - VI. SYNTHESES AND BITTER TASTE OF BPIc (VAL-TYR-PRO-PHE-PRO-PRO-GLY-ILE-ASN-HIS) AND ITS ANALOGS AND FRAGMENTS.
Kanehisa
, p. 97 - 102 (2007/10/02)
In order to investigate the relationship between chemical structure and bitter taste, the bitter peptide BPIc (Val-Tyr-Pro-Phe-Pro-Pro-Gly-Ile-Asn-His) isolated from casein hydrolyzate by Minamiura et al. and its analogs and fragments were synthesized. BPIc, whose threshold value of bitter taste was 0. 05 mm, was found to be one of the most bitter compounds, like quinine and phenylthiourea. However, left bracket Gly**5**,**6 right bracket - and left bracket Gly**9**,**1**0 right bracket -BPIc, and N-terminal octa- and heptapeptide fragments of BPIc possessed much weaker bitterness than BPIc. The results suggested that 5,6-proline and the basic nature of C-terminal are necessary for the strong bitterness exhibited by BPIc.