16194-11-9

Basic information

• Product Name: Glycine lauryl ester hydrochloride
• Synonyms: glycine lauryl ester hydrochloride;GLYCINE LAURYL ESTER HCL
• CAS NO: 16194-11-9
• Molecular Formula: C14H30ClNO2
• Molecular Weight: 279.85
• EINECS: 1312995-182-4
• Mol File: 16194-11-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 95 °C(Solv: water (7732-18-5); methanol (67-56-1))
• Boiling Point: 347.7 °C at 760 mmHg
• Flash Point: 164.1 °C
• Appearance: White crystalline powder
• Vapor Pressure: 3.73E-05mmHg at 25°C
• CAS DataBase Reference: Glycine lauryl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine lauryl ester hydrochloride(16194-11-9)
• EPA Substance Registry System: Glycine lauryl ester hydrochloride(16194-11-9)

Safety Data

• Hazardous Substances Data: 16194-11-9(Hazardous Substances Data)

Usage

General Description

Glycine lauryl ester hydrochloride, also known as glycine lauroyl ester hydrochloride, is a chemical compound used primarily as a surfactant and emulsifier in various personal care and cleaning products. It is derived from glycine, a naturally occurring amino acid, and lauryl alcohol, which is derived from coconut or palm oils. Glycine lauryl ester hydrochloride is typically added to shampoos, body washes, facial cleansers, and other personal care products to help create a foamy lather and improve the spreadability of the product. In cleaning products, it helps to lift dirt and oil from surfaces and improve the overall cleaning performance. Glycine lauryl ester hydrochloride is considered safe for use in cosmetics and personal care products when used in accordance with regulations and guidelines.

InChI:InChI=1/C14H29NO2.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-17-14(16)13-15;/h2-13,15H2,1H3;1H

Upstream product

• 112-53-8 1-dodecyl alcohol 
• 6000-43-7 2-aminoethanoic acid hydrochloride 
• 56-40-6 glycine 

Relevant articles and documents

Novel skin permeation enhancers based on amino acid ester ionic liquid: Design and permeation mechanism

This study developed novel ionic liquids (ILs) based on amino acids. We first screened 15 methyl amino acid ester hydrochlorides ([AAC1]Cl) for their skin permeation enhancements using 5-Fluorouracil (5-Fu) and Hydrocortisone (HC) as model drugs. Glycine methyl ester hydrochloride ([GlyC1]Cl), L-proline methyl ester hydrochloride ([L-ProC1]Cl), and L-leucine methyl ester hydrochloride ([L-LeuC1]Cl) were selected, and their ester sites were modified with different carbon chains (C8 and C12). The resulting ILs showed improved permeation to the two drugs. TEWL and CLSM assays revealed the moderation effects of the modified ILs on skin barrier function, whereas L-proline dodecyl ester hydrochloride ([ProC12]Cl) and L-leucine dodecyl ester hydrochloride ([L-LeuC12]Cl) exhibited the strongest activities. Permeation mechanisms were further investigated by ATR-FTIR, solid-NMR, SEM, and TEM analyses. The results suggested that [L-ProC12]Cl and [L-LeuC12]Cl combined the advantages of amino acid esters and IL solvent and could interact with the intercellular lipid domain by the multi-functions of lipid fluidization and lipid extraction, which were observed in a dosage- and time-dependent manner. Additionally, pathological examination suggested that the amino acid ester-based ILs (AAE-ILs) had good biocompatibility. In conclusion, this study has generated novel chemical penetration enhancers (CPEs) based on AAE-ILs and may be potentially utilized in drug transdermal delivery systems (TDDSs).

SYNTHESIS AND BACTERICIDAL ACTIVITY OF AMINO ACID HIGHER ESTER HYDROCHLORIDES

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