161988-89-2

Basic information

• Product Name: 1-bromo-4-ethyl-2-nitroBenzene
• Synonyms: 1-bromo-4-ethyl-2-nitroBenzene
• CAS NO: 161988-89-2
• Molecular Weight: 230.061
• Mol File: 161988-89-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-bromo-4-ethyl-2-nitroBenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-4-ethyl-2-nitroBenzene(161988-89-2)
• EPA Substance Registry System: 1-bromo-4-ethyl-2-nitroBenzene(161988-89-2)

Safety Data

• Hazardous Substances Data: 161988-89-2(Hazardous Substances Data)

Usage

Brominated nitrobenzene derivative

A type of organic compound derived from nitrobenzene by introducing a bromine atom Enhances the properties and reactivity of the original nitrobenzene.

Nitro group

A functional group (-NO2) attached to the benzene ring Contributes to the compound's chemical reactivity and properties.

Ethyl group

A functional group (-C2H5) attached to the benzene ring Influences the compound's structure and reactivity.

Common uses

Building block in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and dyes Demonstrates the compound's versatility and importance in the chemical industry.

Production of polymers

Used as a monomer or reactant in polymerization processes Highlights its role in creating new materials with specific properties.

Intermediate in organic synthesis

Used as a stepping stone to produce other organic compounds Indicates its involvement in multi-step synthesis processes.

Physical state

Colorless to pale yellow liquid at room temperature Describes the appearance and state of the compound under standard conditions.

Hazardous properties

Harmful if inhaled, absorbed through the skin, or ingested Emphasizes the need for proper handling and safety precautions when working with the compound.

Upstream product

• 38383-27-6 1-(4-bromo-3-nitro-phenyl)-ethanol 
• 18640-58-9 3-nitro-4-bromoacetophenone 
• 1585-07-5 1-bromo-4-ethylbenzene 
• 3663-35-2 4-ethyl-2-nitroaniline 

Downstream Products

• 1365987-68-3 (S)-4-ethyl-7-(2-but-3-enyl)-1-(toluene-4-sulfonyl)-1H-indole 
• 1365987-72-9 (S)-3-[4-ethyl-1-(toluene-4-sulfonyl)-1H-indol-7-yl]-butan-1-ol 
• 1365987-76-3 (S)-3-[4-ethyl-1-(toluene-4-sulfonyl)-1H-indol-7-yl]butyric acid 
• 1365987-80-9 (8S)-4-ethyl-8-methyl-1-(toluene-4-sulfonyl)-7,8-dihydro-1H-1-aza-as-indacen-6-one 
• 1365987-84-3 (8S)-4-ethyl-8-methyl-6-methylene-1-(toluene-4-sulfonyl)-1,6,7,8-tetrahydro-1-aza-as-indacene 
• 1365987-88-7 (8S)-4-ethyl-6,8-dimethyl-1-(toluene-4-sulfonyl)-1,8-dihydro-1-aza-as-indacene 
• 1365987-90-1 (6R,8S)-4-ethyl-6,8-dimethyl-1-(toluene-4-sulfonyl)-1,6,7,8-tetrahydro-1-aza-as-indacene 
• 107438-53-9 cis-trikentrin A 
• 1443436-95-0 (E)-tert-butyl 4-ethyl-7-{3-oxo-3-[2-oxo-5-(trityloxymethyl)pyrrolidin-1-yl]prop-1-enyl}-1H-indole-1-carboxylate 
• 161988-75-6 (E)-methyl 3-(1-benzyl-4-ethyl-1H-indol-7-yl)but-2-enoate 
• 1443436-98-3 (S)-3-(1-benzyl-4-ethyl-1H-indol-7-yl)butanoic acid 
• 1443437-02-2 methyl (3R)-3-(1-benzyl-4-ethyl-1H-indol-7-yl)butanoate 
• 1443437-03-3 4-(1-benzyl-4-ethyl-1H-indol-7-yl)-1,1-dibromopentan-2-one 
• 1443437-04-4 (S)-4-(1-benzyl-4-ethyl-1H-indol-7-yl)pentanoic acid 

Relevant articles and documents

Substituted amide phenol compound and its preparation method, pharmaceutical composition and use thereof

The invention discloses substituted-amide phenolic compounds, their preparation method, a pharmaceutical composition and an application thereof. The compounds have a structure as shown in the general formula I, wherein Z, L and Q are as defined in the spe

Total synthesis of (+)-trans-trikentrin A

Several syntheses have already been reported for cis-trikentrins and herbindoles, which are indole alkaloids unsubstituted at the C2 and C3 positions that bear a trans-1,3-dimethylcyclopentyl unit. Herein, we describe the first asymmetric and stereoselective synthesis of the more challenging trans-trikentrin A as its naturally occurring isomer. Different approaches were investigated and the strategy of choice was a combination of an enzymatic kinetic resolution and a thallium(III)-mediated ring contraction. The antiproliferative activities of the natural product and related intermediates have been tested against human tumor cell lines, leading to the discovery of new compounds with potent antitumor activity. Simple target? Take a look again! The first stereoselective synthesis of a trans-trikentrin is described (see scheme). In contrast, all cis-related natural products have already been synthesized. An enzymatic kinetic resolution and a ring contraction are the key steps. Potent antitumor compounds have been discovered during this study. Copyright

A diastereoselective total synthesis of trans-trikentrin A: A ring contraction approach

(Chemical Equation Presented) A new route to obtain the polyalkylated indole (±)-trans-trikentrin A was developed. The synthesis of this natural alkaloid features a thallium(III)-mediated ring contraction reaction to obtain the trans-1,3-disubstituted five-membered ring in a diastereoselective manner. Thallium(III) is chemoselective in this rearrangement, reacting with the olefin without oxidation of the indole moiety. Other key transformations are the Bartoli's reaction to construct the heterocyclic ring and a Heck coupling to add the carbons atom that will originate the nonaromatic cycle.