3663-35-2

Basic information

• Product Name: 4-ethyl-2-nitro-aniline
• Synonyms: 4-ethyl-2-nitro-aniline
• CAS NO: 3663-35-2
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol File: 3663-35-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 45-47 °C
• Boiling Point: 314°Cat760mmHg
• Flash Point: 143.7°C
• Appearance: /
• Density: 1.218g/cm³
• Vapor Pressure: 0.000479mmHg at 25°C
• Refractive Index: 1.598
• PKA: 0.45±0.10(Predicted)
• CAS DataBase Reference: 4-ethyl-2-nitro-aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethyl-2-nitro-aniline(3663-35-2)
• EPA Substance Registry System: 4-ethyl-2-nitro-aniline(3663-35-2)

Safety Data

• Hazardous Substances Data: 3663-35-2(Hazardous Substances Data)

Usage

General Description

4-ethyl-2-nitro-aniline is a chemical compound with the molecular formula C8H10N2O2. It is a yellow crystalline solid that is mainly used in the production of dyes and pigments, as well as in organic synthesis. It is classified as a nitroamine, which means it contains both a nitro group and an amine group. The compound is considered to be a hazardous material and should be handled with care. It is important to follow safety protocols and guidelines when working with 4-ethyl-2-nitro-aniline to avoid potential health hazards.

InChI:InChI=1/C8H10N2O2/c1-2-6-3-4-7(9)8(5-6)10(11)12/h3-5H,2,9H2,1H3

Upstream product

• 123-91-1 1,4-dioxane 
• 589-16-2 4-aminoethylbenzene 
• 3663-34-1 N-(4-ethylphenyl)acetamide 
• 50321-08-9 (4-ethyl-2-nitro-phenyl)-carbamic acid ethyl ester 
• 3663-33-0 acetic acid-(4-ethyl-2-nitro-anilide) 
• 1585-07-5 1-bromo-4-ethylbenzene 

Downstream Products

• 848589-59-3 2-[3-(4-ethyl-2-nitro-phenylamino)-propyl]-isoindole-1,3-dione 
• 109097-05-4 1-(4-ethyl-2-nitro-anilino)-D-1-deoxy-ribitol 
• 116599-06-5 4-ethyl-o-phenylenediamine; dihydrochloride 
• 1124-38-5 4-ethyl-1,2-phenylenediamine 
• 368-71-8 4-(trifluoromethyl)-1,2-phenylenediamine 
• 1261225-72-2 4-ethyl-2-iodo-6-nitroaniline 
• 1261225-73-3 1-ethyl-3-iodo-5-nitrobenzene 
• 1261225-74-4 3-ethyl-5-iodoaniline 
• 123158-66-7 3-bromo-5-ethyl-nitrobenzene 
• 123158-68-9 3-bromo-5-ethylaniline 
• 123158-73-6 3-Chloro-5-ethylnitrobenzene 
• 72572-18-0 6-ethylbenzimidazole 
• 1095636-39-7 1,2-dibromo-5-ethyl-3-nitrobenzene 
• 123158-72-5 6-chloro-4-ethyl-2-nitroaniline 

Relevant articles and documents

Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis

Liver fructose-1,6-bisphosphatase (FBPase) is a key enzyme in the gluconeogenesis, and its inhibitors are expected to be novel antidiabetic agents. Herein, a series of new indole and benzofuran analogues were designed and synthesized to evaluate the inhib

Next Generation of Guanidine Quinoline Copper Complexes for Highly Controlled ATRP: Influence of Backbone Substitution on Redox Chemistry and Solubility

Ligands DMEG6etqu, TMG6etqu, DMEG6buqu, and TMG6buqu were developed on the basis of guanidine quinoline (GUAqu) ligands 1,3-dimethyl-N-(quinolin-8-yl)imidazolidin-2-imine (DMEGqu) and 1,1,3,3-tetramethyl-2-(quinolin-8-yl)guanidine (TMGqu). These ligands feature an alkyl substituent at the C6 of the quinoline backbone. The synthetic strategy developed here enables inexpensive syntheses of any kind of C6-substituted GUAqu ligands. On one hand, the alkylation increases the solubility of corresponding copper complexes in apolar atom transfer radical polymerization (ATRP) monomers like styrene. On the other hand, it has a significant electronic influence and thus an effect on the donor properties of the new ligands. Seven CuI and CuII complexes of DMEG6etqu and TMG6etqu have been crystallized and were studied with regard to their structural and electrochemical properties. CuI and CuII complexes of DMEG6buqu and TMG6buqu turned out to be perfectly soluble in pure styrene even at room temperature, which makes them excellent catalysts in the ATRP of apolar monomers. The key characteristics of the ATRP equilibrium, KATRP and kact, were determined for the new complexes. In addition, we used our recently developed DFT methodology, NBO analysis, and isodesmic reactions to predict the influence of the introduced alkyl substituents. It turned out that high conformational freedom in the complex structures leads to a significant uncertainty in prediction of the thermodynamic properties.

Concise total synthesis of

An efficient nine-step total synthesis of the annulated indole natural products.