1619929-48-4Relevant articles and documents
Functionalized Bipyrroles and Pyrrolyl-Aminopyrones from Acylethynylpyrroles and Diethyl Aminomalonate
Gotsko, Maxim D.,Kireeva, Victoriya V.,Saliy, Ivan V.,Sobenina, Lyubov N.,Trofimov, Boris A.,Ushakov, Igor A.
, (2021/12/29)
An efficient method for the synthesis of 1H,1?H-2,3?-bipyrroles (up to 72% yield) by the cyclocondensation of easily available 2-(acylethynyl)pyrroles with diethyl aminomalonate hydrochloride has been developed. The reaction proceeds under reflux in MeCN
From 4,5,6,7-tetrahydroindoles to 3- or 5-(4,5,6,7-tetrahydroindol-2-yl)isoxazoles in two steps: A regioselective switch between 3- and 5-isomers
Sobenina, Lyubov N.,Tomilin, Denis N.,Gotsko, Maxim D.,Ushakov, Igor A.,Mikhaleva, Albina I.,Trofimov, Boris A.
, p. 5168 - 5174 (2014/12/10)
(4,5,6,7-Tetrahydroindol-2-yl)alkynes, synthesized by cross-coupling of 4,5,6,7-tetrahydroindoles with aroyl(hetaroyl)bromoalkynes or ethyl bromopropynoate in the presence of K2CO3, regioselectively cyclize with hydroxylamine to either 3- or 5-(4,5,6,7-tetrahydroindol-2-yl)isoxazoles depending on the acidity of the reaction mixture: in the presence of acetic acid 3-isomers are formed (ca. 100% selectivity), while under neutral conditions the reaction is switched to 5-isomers (94-97% selectivity).
