3015-19-8

Usage

Uses

Used in Pharmaceutical Industry:
(1s,3s,5R,7S)-2-azaadaMantan-1-ol is used as a pharmaceutical compound for its unique stereochemistry and functional groups, which may contribute to the development of new drugs or drug candidates with specific therapeutic effects.
Used in Chemical Industry:
(1s,3s,5R,7S)-2-azaadaMantan-1-ol is used as a chemical intermediate or building block for the synthesis of other complex organic molecules, taking advantage of its unique structure and reactivity.

Upstream product

• 85616-64-4 3-Azidonoradamantane 
• 127666-15-3 tricyclo[3.3.1.0^3,7]nonyl-3-isocyanate 
• 85616-63-3 N-Noradamant-3-ylacetamide 
• 67064-09-9 3-noradamantanecarboxylic acid chloride 
• 28224-43-3 tricyclo[3.3.1.0^3,7]nonan-3-amine 
• 16200-53-6 3-noradamantanecarboxylic acid 
• 66077-97-2 spiro[bicyclo[3.3.1]nonane-3,2'-[1,3]dioxolan]-7-one 
• 770-15-0 bicyclo[3.3.1]nonane-3,7-dione 
• 17933-29-8 7-methylenebicyclo[3.3.1]nonan-3-one 
• 5001-18-3 1,3-adamantandiol 
• 157521-81-8 7,7-ethylenedioxybicyclo[3.3.1]nonan-3-one oxime 
• 905832-09-9 N-benzyloxycarbonyl-2-azaadamantane-1-ol 
• 85616-67-7 1-Methoxy-2-azaadamantane 
• 770-15-0 bicyclo<3.3.1>nonane-3,7-dione 

Downstream Products

• 57625-08-8 2-azatricyclo[3.3.1.1^3,7]dec-2-yloxidanyl 
• 768-41-2 2-azatricyclo[3.3.1.13,7 ]decane 

Relevant academic research and scientific papers

COMPOUNDS CONTAINING AN ALICYCLIE STRUCTURE AND ANTI-TUMOR APPLICATION

This invention relates with anti-tumor activities of new compounds containing an adamantyl group or analogs thereof. The invention also relates with the medication applications of anti-tumor and other diseases by this kind of compounds with the combination of S, P, T structures containing adamantyl group and the formation of stereoisomer, tautomers, prodrug, pharmaceutically acceptable salts, complex salts or solvates to their anticancer application and anticancer agents, which have the following general formula:

2-Azaadamantane N-oxyl (AZADO) and 1-Me-AZADO: Highly efficient organocatalysts for oxidation of alcohols

Development of a stable nitroxyl radical class of catalysts, 2-azaadamantane N-oxyl (AZADO) and 1-Me-AZADO, for highly efficient oxidation of alcohols is described. AZADO and 1-Me-AZADO exhibit superior catalytic proficiency to TEMPO, converting various sterically hindered alcohols to the corresponding carbonyl compounds in excellent yields. Copyright

Photolytic Generation of Anti-Bredt Imines from 1-Azidobicyclooctane, 1-Azidobicyclononane, and 3-Azidonoradamantane

Photolysis of 1-azidobicyclooctane (18), 1-acidobicyclononane (24), and 3-azidonoradamantane (37) generated the corresponding bridgehead imines 12a, 13, 14, 15, and 16, respectively.These bridgehead imines were trapped spontaneously with sol

Neighboring Group Effects in the β-Halo Amines. Synthesis and Solvolytic Reactivity of the anti-4-Substituted 2-Azaadamantyl System

The syntheses of anti-4-chloro-2-n-propyl-2-azaadamantane (1) and 2-(2-chloroethyl)-2-azaadamantane (8) were carried out.When 1 was subjected to solvolysis in aqueous methanolic NaOH, a rate enhancement of ca. 2*106 was observed at 25 deg C, compared to that for 2-chloroadamantane (23).The solvolytic rate of 1 is comparable to that of an aliphatic β-halo amine, and because of the absence of a kinetic rate component due to solvent assistance in the adamantyl system, the observed enhancement may represent the rate-limiting case for the substituted β-chloroethylamines.The solvolysis rate of 8 was 2.5-fold less than that of 1, despite an expected decrease in activation energy.The lower rate for 8 may be due to its larger negative entropy of activation compared to that of 1.Indirect evidence was found for the existence of azridinium ion intermediates during solvolysis, but their direct observation remains to be accomplished.