1620003-52-2Relevant academic research and scientific papers
Facile access to functionalized spiro[indoline-3,2′-pyrrole]-2, 5′-diones via post-Ugi domino Buchwald-Hartwig/Michael reaction
Sharma, Nandini,Li, Zhenghua,Sharma, Upendra K.,Van Der Eycken, Erik V.
supporting information, p. 3884 - 3887 (2014/08/18)
A novel access to spiro[indoline-3,2′-pyrrole]-2,5′-diones is presented via a palladium-catalyzed post-Ugi cascade cyclization approach involving a Buchwald-Hartwig/Michael reaction sequence. The method allows the easy construction of a library of spirooxindoles in moderate to good yields starting from readily available precursors. In addition, alkynoic acids are replaced with α,β-unsaturated acids leading to variably substituted spirooxindoles.
