1620023-75-7

Upstream product

• 53186-45-1 N₁-(7-chloroquinolin-4-yl)butane-1,4-diamine 
• 586345-73-5 2-(chloromethyl)-5-(benzyloxy)-1-methylpyridin-4(1H)-one 
• 501-30-4 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 
• 15771-06-9 5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one 
• 100-44-7 benzyl chloride 
• 89539-51-5 5-(benzyloxy)-2-(hydroxymethyl)-1-methyl-1,4-dihydropyridin-4-one 
• 86-98-6 4,7-dichloroquinoline 

Relevant academic research and scientific papers

Kojic acid derived hydroxypyridinone-chloroquine hybrids: Synthesis, crystal structure, antiplasmodial activity and β-haematin inhibition

Aminochloroquinoline-kojic acid hybrids were synthesized and evaluated for β-haematin inhibition and antiplasmodial activity against drug resistant (K1) and sensitive (3D7) strains of Plasmodium falciparum. Compound 7j was the most potent compound in both strains (IC503D7 = 0.004 μM; IC50K1 = 0.03 μM) and had the best β-haematin inhibition activity (0.07 IC50 equiv vs 1.91 IC 50 equiv for chloroquine). One compound 8c was found to be equipotent in both strains (IC50 = 0.04 μM).