162007-08-1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 367968-06-7 methyl (2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}-5-hydroxypentanoate 
• 192314-71-9 methyl (S)-2-N,N-di(tert-butoxycarbonyl)amino-5-oxopentanoate 
• 206128-03-2 (S)-dimethyl 2-(bis(tert-butoxycarbonyl)amino)pentanedioate 
• 59279-60-6 dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate 
• 56-86-0 L-glutamic acid 
• 162007-07-0 methyl (2S)-(tert-butoxycarbonylamino)-5-hydroxypentanoate 
• 72086-72-7 N-tert-butoxycarbonylglutamic acid methyl ester 
• 162007-09-2 methyl (2S)-(tert-butoxycarbonylamino)-5-methanesulfonyloxypentanoate 

Downstream Products

• 162007-11-6 ethyl 3-[[(4S)-(tert-butoxycarbonylamino)-4-(methoxycarbonyl)butyl]amino]benzoate 
• 64896-37-3 methyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-norvalinate 
• 162007-18-3 diethyl N-[(4S)-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoylamino]-4-methoxycarbonylbutyl]-L-glutamate 
• 162007-17-2 methyl N^α-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-N^δ-(3-ethoxycarbonylphenyl)-L-ornithinate 
• 162007-16-1 methyl N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-N^δ-(3-ethoxycarbonylphenyl)-L-ornithinate 

Relevant academic research and scientific papers

Synthesis of Imidazole and Histidine-Derived Cross-Linkers as Analogues of GOLD and Desmosine

Amino acid derivatives with a central cationic heterocyclic core (e.g., imidazolium) are biologically relevant cross-linkers of proteins and advanced glycation end (AGE) products. Here, imidazolium-containing cross-linkers were synthesized from imidazole or histidine by N-alkylation employing aspartate- and glutamate-derived mesylates as key step. Biological investigations were carried out to probe the biocompatibility of these compounds.

Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. III. Synthesis and biological properties of N(ω)-masked ornithine analogs

The glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutam ic acid (1b, TNP-351) and the related compound (1a), was replaced with various N(ω)-acyl-, sulfonyl-, carbamoyl- and aryl-2,ω-diaminoalkanoic acids,