1620097-93-9Relevant academic research and scientific papers
Mild chlorodifluoroacylation of indoles via self-activation of sodium chlorodifluoroacetate
Williams, Thomas J.,Greaney, Michael F.
, p. 4024 - 4027 (2014)
A mild acylation of N-alkylindoles is reported using sodium chlorodifluoroacetate (SCDA) to synthesize useful chlorodifluoroketones. Friedel-Crafts reactivity of carboxylate salts is unusual and is not observed in similar electron-deficient acetate salts such as sodium trifluoroacetate. Mechanistic experiments indicate that the characteristic ability of SCDA to generate difluorocarbene is responsible for the reaction pathway via self-activation to form the active ester.
