1620133-40-5Relevant academic research and scientific papers
Synthesis and antiviral activity of amino-acid conjugates of glycyrrhetic acid
Baltine Jr.,Khudobko,Mikhailova,Baltina,Fedorova,Orshanskaya, Ya. A.,Zarubaev,Kiselev
, p. 473 - 477 (2014)
Conjugates of glycyrrhetic acid (GLA) with amino acids (L-isoleucine, -leucine, -valine, and -phenylalanine) were synthesized by the acid-chloride method using methyl or tert-butyl esters of the acids. Tests in MDCK cell culture showed that the GLA conjugate with phenylalanine exhibited high antiviral activity against influenza A/H1N1/pdm09 virus (ED50 = 4.4 μg/mL, SI = 161).
