1620145-28-9Relevant academic research and scientific papers
Organocatalytic domino sequence to asymmetrically access spirocyclic oxindole-α-methylene-γ-lactams
Xie, Zhen-Zhen,Qian, Yu-Lun,Zheng, Yu,Zhao, Qing-Lan,Xiao, Jun-An,Xiang, Hao-Yue,Chen, Kai,Yang, Hua
, (2021)
An asymmetric allylic alkylation-lactamization domino sequence of 3-aminooxindoles with Morita-Baylis-Hillman carbonates catalyzed by quinidine derivative (β-ICD) was developed. And a series of chiral spirocyclic oxindole-α-methylene-γ-lactams have been facilely prepared in good yields and stereoselectivities. This developed protocol would broaden the utilization of Morita-Baylis-Hillman carbonates in asymmetric construction of spirocyclic oxindoles.
