1620146-08-8Relevant academic research and scientific papers
Mitochondria-targeted cancer therapy using a light-up probe with aggregation-induced-emission characteristics
Hu, Qinglian,Gao, Meng,Feng, Guangxue,Liu, Bin
, p. 14225 - 14229 (2014)
Subcellular organelle-specific reagents for simultaneous tumor targeting, imaging, and treatment are of enormous interest in cancer therapy. Herein, we present a mitochondriatargeting probe (AIE-mito-TPP) by conjugating a triphenylphosphine (TPP) with a fluorogen which can undergo aggregation-induced emission (AIE). Owing to the more negative mitochondrial membrane potential of cancer cells than normal cells, the AIE-mito-TPP probe can selectively accumulate in cancer-cell mitochondria and light up its fluorescence. More importantly, the probe exhibits selective cytotoxicity for studied cancer cells over normal cells. The high potency of AIE-mito-TPP correlates with its strong ability to aggregate in mitochondria, which can efficiently decrease the mitochondria membrane potential and increase the level of intracellular reactive oxygen species (ROS) in cancer cells. The mitochondrial light-up probe provides a unique strategy for potential image-guided therapy of cancer cells.
A fluorescent light-up probe with AIE characteristics for specific mitochondrial imaging to identify differentiating brown adipose cells
Gao, Meng,Sim, Choon Kiat,Leung, Chris Wai Tung,Hu, Qinglian,Feng, Guangxue,Xu, Feng,Tang, Ben Zhong,Liu, Bin
, p. 8312 - 8315 (2014)
We report the design and synthesis of a specific mitochondrial fluorescent probe AIE-MitoGreen-1 with AIE characteristics to monitor the mitochondrial morphology changes and identify the differentiation process of living brown adipose cells. The probe AIE-MitoGreen-1 has significant advantages such as high cell-permeability, good mitochondrial retention, low background fluorescence, large Stokes shift, and low toxicity. This journal is the Partner Organisations 2014.
Salicylaldehyde azine derivate and preparation method thereof and water-phase light trapping system constructed thereby
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Paragraph 0045; 0046, (2018/11/22)
The invention belongs to the field of supermolecular photochemistry, and specifically relates to a salicylaldehyde azine derivate and a preparation method thereof and a water-phase light trapping system constructed thereby. The salicylaldehyde azine derivate has the structure as shown in the description. The invention also provides a salicylaldehyde azine derivate self-assembly and a water-phase light trapping system constructed thereby, a salicylaldehyde azine derivate and gamma-CD formed pseudorotaxane self-assembly and a water-phase light trapping system constructed thereby; the constructedlight trapping system has the advantages of being stable in structure, simple and convenient to construct, high in energy transmission efficiency and high in antenna effect, and has a large application potential in the construction of a supramolecular self-assembly light trapping system. The invention also provides the preparation method of the salicylaldehyde azine derivate. The synthesizing method is simple, convenient, efficient, and high in yield.
