1620194-09-3

Basic information

• Product Name: N-(2-(pyridin-2-yl)propan-2-yl)benzamide-2,3,4,5,6-d₅
• Synonyms: N-(2-(pyridin-2-yl)propan-2-yl)benzamide-2,3,4,5,6-d₅
• CAS NO: 1620194-09-3
• Molecular Weight: 245.265
• Mol File: 1620194-09-3.mol

Chemical Properties

• CAS DataBase Reference: N-(2-(pyridin-2-yl)propan-2-yl)benzamide-2,3,4,5,6-d₅(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(pyridin-2-yl)propan-2-yl)benzamide-2,3,4,5,6-d₅(1620194-09-3)
• EPA Substance Registry System: N-(2-(pyridin-2-yl)propan-2-yl)benzamide-2,3,4,5,6-d₅(1620194-09-3)

Safety Data

• Hazardous Substances Data: 1620194-09-3(Hazardous Substances Data)

Upstream product

• 4165-57-5 bromobenzene-d5 
• 1079-02-3 benzoic acid-2,3,4,5,6-d5 
• 43019-90-5 benzoyl chloride-d5 
• 52568-28-2 2-(pyridin-2-yl)isopropyl amine 
• 2037-26-5 ⁽²⁾H₈-toluene 

Relevant articles and documents

Palladium-Catalyzed Electrochemical C-H Bromination Using NH4Br as the Brominating Reagent

The palladium-catalyzed electrochemical C-H bromination of benzamide derivatives under divided cells is developed, in which NH4Br serves as a brominating reagent and electrolyte. The protocol avoids the use of chemical oxidants and provides an alternative method for the synthesis of aryl bromides.

Nickel-Catalyzed Sulfonylation of C(sp2)–H Bonds with Sodium Sulfinates

The first nickel-catalyzed ortho-sulfonylation of C(sp2)–H bonds with sodium sulfinates directed by (pyridin-2-yl)isopropylamine (PIP-amine) is described. This strategy exhibits a broad substrate scope and good functional group tolerance with high monosulfonylation selectivity. Besides arenes and heteroarenes, the reaction can also be extended to alkenes, providing diverse diaryl and alkyl aryl sulfones in high yields. Furthermore, a plausible Ni(I)/Ni(III) mechanism is outlined based on our experimental results and related precedents. (Figure presented.).

Copper-mediated hydroxylation of arenes and heteroarenes directed by a removable bidentate auxiliary

A copper-mediated C-H hydroxylation of arenes and heteroarenes using our newly developed PIP directing group has been developed. This procedure is scalable and compatible with a wide range of functional groups and heteroarenes, providing an operationally simple protocol for the synthesis of o-hydroxybenzamides. The hydroxylation of nicotinamides gave 4-oxo-1,4-dihydropyridine-3-carboxamides selectively. Preliminary mechanistic studies implicate that a basic ligand-enabled, irreversible, rate-determining CMD step is most likely involved in this process.

Cu(II)-mediated C-S/N-S bond formation via C-H activation: Access to benzoisothiazolones using elemental sulfur

A copper-mediated C-S/N-S bond-forming reaction via C-H activation that uses elemental sulfur has been developed. The addition of TBAI was found to be crucial for the success of this transformation. The method is scalable, shows excellent functional group tolerance, and is compatible with heterocycle substrates, providing efficient and practical access to benzoisothiazolones. The direct diversification of the benzoisothiazolone products into a variety of sulfur-containing compounds is also demonstrated.