162020-86-2Relevant academic research and scientific papers
Synthesis and Activity of an HIV-1 Protease Inhibitor Containing a Contiguous (E)-Olefin-Hydroxyethylene Peptide Mimetic
Keenan, Richard M.,Eppley, Daniel F.,Tomaszek, Thaddeus A.
, p. 819 - 822 (1995)
To investigate the contribution of a key amide bond to HIV Protease inhibition, we designed and synthesized a novel (E)-olefin hydroxyethylene analog.The stereoselective synthesis of this interesting homoallylic alcohol structural motif as well as its bio
