Synthesis and Activity of an HIV-1 Protease Inhibitor Containing a Contiguous (E)-Olefin-Hydroxyethylene Peptide Mimetic

DOI: 10.1016/0040-4039(94)02416-9

Source and publish data:

Tetrahedron Letters p. 819 - 822 (1995)

Update date:2022-09-26

Topics:

Authors:

Keenan, Richard M.

Eppley, Daniel F.

Tomaszek, Thaddeus A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(94)02416-9

To investigate the contribution of a key amide bond to HIV Protease inhibition, we designed and synthesized a novel (E)-olefin hydroxyethylene analog.The stereoselective synthesis of this interesting homoallylic alcohol structural motif as well as its bio

Full text of DOI:10.1016/0040-4039(94)02416-9

Products guided by the article

Product name:(2S,3R)-2-Benzyl-6-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-hexanoic acid methoxy-methyl-amide

Cas No:162020-86-2

R&D Labs maybe for 162020-86-2

Shanghai Hanshare Industry Co.,Ltd.

Contact:86 21 20960688

Address:RM902-903,Building E, Wanda Plaza,No.26,Zhoukang Road, Pudong District, Shanghai, China
Tianjin Ingenochem Technology Co.,Ltd

Contact:+86-22-23677060

Address:Hitech Green Industry Park K2-9-602, Nankai district
HANGZHOU ZHONGCHANG SCIENTIFIC CO.,LTD

Contact:+86-571-88932183

Address:Hangzhou
Nanjing Habo Medical Technology Co., Ltd.

Contact:025－85769882

Address:No.108. Ganjiabian east. Qixia District .Nanjing
Shanghai chemrole co.,ltd

Contact:021-50278900

Address:No.6,Room 201 ,Lane 299,bisheng road ,shanghai ,china

Relevant to this article

Synthesis of the ferrocenyl analogue of clotrimazole drug

Doi:10.1016/j.jorganchem.2016.12.009
(2017)
Studies on the Reaction of Thiiranes with Tributyltin Hydride

Doi:10.1021/jo00107a033
(1995)
Axial shielding of 5d⁸ and 5d⁷ metal centers in dimesitylplatinum complexes with unsaturated chelate ligands: Spectroscopic and spectroelectrochemical studies of four different oxidation states

Doi:10.1021/om00003a019
(1995)
Doi:10.1002/jlcr.2590110208
(1975)
Solvent-free Zn(OTf)2-catalyzed dehydrative cross coupling of propargyl alcohols with diarylphosphine oxides to afford allenylphosphine oxides

Doi:10.1080/10426507.2018.1490281
(2018)
Synthetic studies on oligomycins. Synthesis of the oligomycin B spiroketal and polypropionate portions

Doi:10.1246/bcsj.68.967
(1995)

Article Doi