Synthesis and Activity of an HIV-1 Protease Inhibitor Containing a Contiguous (E)-Olefin-Hydroxyethylene Peptide Mimetic

Article abstract of DOI:10.1016/0040-4039(94)02416-9

To investigate the contribution of a key amide bond to HIV Protease inhibition, we designed and synthesized a novel (E)-olefin hydroxyethylene analog.The stereoselective synthesis of this interesting homoallylic alcohol structural motif as well as its bio