Synthesis and Activity of an HIV-1 Protease Inhibitor Containing a Contiguous (E)-Olefin-Hydroxyethylene Peptide Mimetic

DOI: 10.1016/0040-4039(94)02416-9

Source and publish data:

Tetrahedron Letters p. 819 - 822 (1995)

Update date:2022-09-26

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Authors:

Keenan, Richard M.

Eppley, Daniel F.

Tomaszek, Thaddeus A.

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Article abstract of DOI:10.1016/0040-4039(94)02416-9

To investigate the contribution of a key amide bond to HIV Protease inhibition, we designed and synthesized a novel (E)-olefin hydroxyethylene analog.The stereoselective synthesis of this interesting homoallylic alcohol structural motif as well as its bio

Full text of DOI:10.1016/0040-4039(94)02416-9

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