1620220-76-9

Upstream product

• 433-14-7 4-fluoro-N-methyl-benzenesulfonamide 
• 920-46-7 Methacryloyl chloride 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 

Downstream Products

• 1620220-86-1 6-fluoro-1,3-dimethyl-3-(tosylmethyl)indolin-2-one 
• 1588429-92-8 6-fluoro-1, 3-dimethyl-3-((phenylsulfonyl)methyl)indolin-2-one 

Relevant academic research and scientific papers

Copper-Catalyzed Arylsulfonylation and Cyclizative Carbonation of N-(Arylsulfonyl)acrylamides Involving Desulfonative Arrangement toward Sulfonated Oxindoles

Sulfonated oxindoles are accessed by a Cu(OAc)2-catalyzed three-component reaction of N-(arylsulfonyl)acrylamides, DABSO, and aryldiazonium tetrafluoroborates. This transformation is triggered by the formation of arylsulfonyl radicals in situ from the reaction of aryldiazonium tetrafluoroborates and DABSO. Afterward, the sequential radical addition, radical cyclization, and desulfonylative 1,4-aryl migration take place to provide the final product by the formation of four new bonds in one pot. This procedure shows good functional group tolerance.

Copper-catalyzed arylsulfonylation of N-arylsulfonyl-acrylamides with arylsulfonohydrazides: Synthesis of sulfonated oxindoles

A copper-catalyzed arylsulfonylation of N-arylsulfonyl-acrylamides with sulfonylhydrazides through a tandem radical process was developed. This methodology provided an alternative strategy for the synthesis of sulfonated oxindoles by forming C-S, C-N and C-C bonds in a single operation. the Partner Organisations 2014.