1620230-76-3Relevant academic research and scientific papers
Facile regiospecific synthesis of 2,3-disubstituted indoles from isatins
Dou, Xiaowei,Yao, Weijun,Wen, Shan,Lu, Yixin
supporting information, p. 9469 - 9472 (2014/08/18)
A facile regiospecific synthesis of 2,3-disubstituted indoles from isatins has been developed. Nucleophilic addition of Grignard reagents to commercially available isatins, followed by reduction with borane, afforded an array of structurally diverse 2,3-disubstituted indoles in moderate to good yields. The method described herein represents a novel and very simple approach to synthesize various 2,3-disubstituted indoles, extremely important structural motifs in the pharmaceutical industry and medicinal chemistry. This journal is the Partner Organisations 2014.
