1620320-66-2

Upstream product

• 67-56-1 methanol 
• 1620320-48-0 (S)-3-methyl-2-(4-nitrobenzyl)-2,3,9,10-tetrahydro-8H-[1,2,4]triazino[1,2-a][1,2]diazepine-1,4-dione 
• 1620387-52-1 (S)-1-methoxy-N-(4-nitrobenzyl)-1-oxopropan-2-aminium chloride 
• 555-16-8 4-nitrobenzaldehdye 
• 1620320-32-2 (S)-2-(but-3-en-1-yl)-5-methyl-4-(4-nitrobenzyl)-1,2,4-triazinane-3,6-dione 
• 1640032-51-4 C₂₁H₃₀N₄O₇ 

Relevant academic research and scientific papers

Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process

Herein, we report an unprecedented, short and diastereo-selective synthesis of newly reported aza-diketopiperazine (aza-DKP) scaffolds starting from amino acids. The strategy is based on a Rh(i)-catalyzed hydroformylative cyclohydrocarbonylation of allyl-substituted aza-DKP, followed by a diastereoselective functionalization of the platform. This methodology allows the synthesis of novel bicyclic and tricyclic aza-DKP scaffolds incorporating six- or seven-membered rings, with potential applications in medicinal chemistry. This journal is the Partner Organisations 2014.