162045-29-6

Basic information

• Product Name: 1-BOC-4-(2-HYDROXYMETHYL-PHENYLAMINO)-PIPERIDINE
• Synonyms: 1-BOC-4-(2-HYDROXYMETHYL-PHENYLAMINO)-PIPERIDINE;tert-butyl-4-(2-(hydroxymethyl)phenylamino)piperidine-1-carboxylate;tert-butyl 4-[2-(hydroxymethyl)anilino]piperidine-1-carboxylate
• CAS NO: 162045-29-6
• Molecular Formula: C₁₇H₂₆N₂O₃
• Molecular Weight: 306.4
• Mol File: 162045-29-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 466.398 °C at 760 mmHg
• Flash Point: 235.869 °C
• Appearance: /
• Density: 1.163 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-BOC-4-(2-HYDROXYMETHYL-PHENYLAMINO)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-(2-HYDROXYMETHYL-PHENYLAMINO)-PIPERIDINE(162045-29-6)
• EPA Substance Registry System: 1-BOC-4-(2-HYDROXYMETHYL-PHENYLAMINO)-PIPERIDINE(162045-29-6)

Safety Data

• Hazardous Substances Data: 162045-29-6(Hazardous Substances Data)

Usage

Uses

1-Boc-4-(2-hydroxymethylphenylamino)piperidine is used as a reactant in the synthesis of novel and selective serotonin 5-HT6 receptor ligands.

InChI:InChI=1/C17H26N2O3/c1-17(2,3)22-16(21)19-10-8-14(9-11-19)18-15-7-5-4-6-13(15)12-20/h4-7,14,18,20H,8-12H2,1-3H3

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 5344-90-1 2-Aminobenzyl alcohol 

Downstream Products

• 162045-30-9 1-(N-t-butyloxy-carbonyl-4-piperidinyl)-4H-3,1-benzoxazin-2(1H)-one 
• 885484-80-0 4-(2-ethoxycarbonylmethoxymethyl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester 
• 945845-03-4 4-(2-carboxymethoxymethyl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester 
• 162042-41-3 4-{3-Methoxy-4-[4-(2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperidine-1-carbonyl]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester 
• 356072-38-3 1-(tert-butoxycarbonyl)-4-[(2-phthalimidylmethylphenyl)amino]piperidine 
• 162042-44-6 1-(1-(4-((N-acetyl-4-piperidinyl)oxy)-2-methoxybenzoyl)piperidin-4-yl)-4H-3,1-benzoxazin-2(1H)-one 
• 162045-26-3 1-(1-4-(1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxyl-2-methoxybenzoyl)piperidin-4-yl)-1,4-dihydrobenz(d)(1,3)oxazin-2-one 

Relevant articles and documents

Synthesis of new benzoxazinone derivatives as neuropeptide Y5 antagonists for the treatment of obesity

Screening of our internal chemical collection against the neuropeptide Y5 (NPY Y5) receptor allowed the identification of a benzoxazine derivative 5f as a hit that showed moderate affinity (IC50 = 300 nM). With the aim of improving the in vitro potency, a series of 2-benzoxazinone derivatives have been synthesized and tested for NPY Y5 activity. Most of the compounds were found to be potent and selective NPY Y5 antagonists having nanomolar binding affinities for the NPY Y5 receptor and showing functional antagonism in the forskolin-induced cyclic AMP test. Prelimminary studies in order to understand the structure-activity relationship were undertaken. Selected compounds were further evaluated for in vivo efficacy, affording the lead compound 2-[4-(8-methyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)piperidin-1-yl] -N-(9-oxo-9H-fluoren-3-yl)acetamide 5p, which displayed in vivo activity reducing food intake in rodents.

Tocolytic oxytocin receptor antagonists

This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

1--2-methoxybenzoyl>piperidin-4-yl>-4H-3,1-benzoxazin-2(1H)-one (L-371,257): A New, Orally Bioavailable, Non-Peptide Oxytocin Antagonist

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