16205-46-2

Basic information

• Product Name: Pyrazolo[1,5-a]pyridine-3-carboxylic acid
• Synonyms: PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID;H-pyrazolo[1,5-a]pyridine-3-carboxylic acid;Pyrazolo[1,5-a]pyridine-3-carboxylic acid ,97%;Pyrazolo pyridine-3-carboxylic acid;razolo[1,5-a]pyridine-3-carboxylic acid
• CAS NO: 16205-46-2
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.15
• Mol File: 16205-46-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 199 °C
• Appearance: /
• Density: 1.418 g/cm³
• Refractive Index: 1.676
• Storage Temp.: 2-8°C
• PKA: -0.61±0.41(Predicted)
• CAS DataBase Reference: Pyrazolo[1,5-a]pyridine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazolo[1,5-a]pyridine-3-carboxylic acid(16205-46-2)
• EPA Substance Registry System: Pyrazolo[1,5-a]pyridine-3-carboxylic acid(16205-46-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 16205-46-2(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

Uses

Pyrazolo[1,5-a]pyridine-3-carboxylic acid is a useful intermediate for the improved synthesis of pyrazolo[1,5-a]pyridine-3-carboxylic acid derivatives.

InChI:InChI=1/C8H6N2O2/c11-8(12)6-5-9-10-4-2-1-3-7(6)10/h1-5H,(H,11,12)

Upstream product

• 63237-84-3 methyl pyrazolo<1,5-a>pyridine-3-carboxylate 
• 16205-44-0 Pyrazolo<1,5-a>pyridin-3-carbonsaeureethylester 

Downstream Products

• 221470-47-9 3-(4-phenylpiperazin-1-ylmethyl)-pyrazolo[1,5-a]pyridine 
• 221470-50-4 FAUC 113 
• 1383675-76-0 3-(o-tolyl)pyrazolo[1,5-a]pyridine 
• 1383675-63-5 3-(m-tolyl)pyrazolo[1,5-a]pyridine 
• 1383675-64-6 3-(p-tolyl)pyrazolo[1,5-a]pyridine 
• 1383675-82-8 3-(3-methoxyphenyl)pyrazolo[1,5-a]pyridine 
• 1383675-62-4 3-(4-fluorophenyl)pyrazolo[1,5-a]pyridine 
• 1383675-80-6 3-(3-fluorophenyl)pyrazolo[1,5-a]pyridine 

Relevant articles and documents

Discovery of potent colony-stimulating factor 1 receptor inhibitors by replacement of hinge-binder moieties

Tumor-associated macrophages (TAMs) are predominantly associated with tumor growth. Colony-stimulating factor 1 receptor (CSF1R) acts as a key regulator of TAM survival and differentiation and is a molecular target for cancer therapies. Herein, novel CSF1

2-pyridine substituted urea structural small molecule compounds as well as synthesis and application thereof

The invention relates to 2-pyridine substituted urea structural small molecule compounds as well as synthesis and application thereof. Specifically, the invention discloses the compounds represented by a formula (I) shown in the specification, enantiomers, diastereomers, racemates or a mixture of the compounds, or a pharmaceutically acceptable salt, hydrate and solvate of the compounds, a preparation method of the above materials, and applications of the above materials in preparation of an ASK1 small molecule inhibitor, or medicines for preventing and/or treating diseases related to ASK1, especially liver diseases, lung diseases, cardiovascular diseases, kidney diseases and metabolic diseases.

Development of Structurally Diverse N-Heterocyclic Carbene Ligands via Palladium-Copper-Catalyzed Decarboxylative Arylation of Pyrazolo[1,5-a]pyridine-3-carboxylic Acid

A series of fused non-classical normal N-heterocyclic carbenes, Pyrpy-NHC precursors derived from pyrazolo[1,5-a]pyridines, has been prepared using palladium-copper-catalyzed decarboxylative arylation of pyrazolo[1,5-a]pyridine-3-carboxylic acid. Air-stable palladium and rhodium complexes of these ligands have been synthesized via mild transmetallation of Ag-Pyrpy-NHC. The structural properties of Rh(Pyrpy-NHC)(COD)Cl complexes were determined via X-ray analysis. The measurement of the CO stretching frequencies of dicarbonyl Rh-Pyrpy-NHC complexes revealed that the electron donating strength of Pyrpy-NHC could be tuned by varying the substituents of the aryl group. A catalytic study of the Pd-Pyrpy-NHC complexes revealed promising activity in the Suzuki–Miyaura reaction under ambient atmospheric conditions. (Figure presented.).