1620581-08-9

Upstream product

• 1620581-26-1 C₁₆H₂₁Cl₂N 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 1620581-54-5 2-(2,4-dichloro-5-((2'-methylspiro[cyclohexane-1,3'-indolin]-1'-yl)sulfonyl)phenyl)-2-isobutyl-4-methylpentanenitrile 
• 6306-60-1 2,4-Dichlorophenylacetonitrile 
• 1620581-28-3 C₁₆H₂₀Cl₃NO₂S 

Relevant academic research and scientific papers

Pd(II)-catalyzed meta-C-H olefination, arylation, and acetoxylation of indolines using a U-shaped template

meta-C-H olefination, arylation, and acetoxylation of indolines have been developed using nitrile-containing templates. The combination of a monoprotected amino acid ligand and the nitrile template attached at the indolinyl nitrogen via a sulfonamide linkage is crucial for the meta-selective C-H functionalization of electron-rich indolines that are otherwise highly reactive toward electrophilic palladation at the para-positions. A wide range of synthetically important and advanced indoline analogues are selectively functionalized at the meta-positions.