16206-18-1Relevant articles and documents
Pyrazine-1,4-dioxides fused to heterocyles. 3rd comm. Synthesis and antibacterial activity of substituted pteridine-5,8-dioxides
Binder,Noe,Prager,Turnowsky
, p. 803 - 805 (2007/10/02)
The synthesis of substituted pteridine-5,8-dioxides via reaction of furoxanes with enolizing carbonyl compounds is described. Compounds 5 are obtained either through reaction of chloro pyrimidines 1 with sodium azide, or through diazotization of hydrazino pyrimidine 2 and subsequent thermal decomposition of 3 or through nucleophilic displacement of methoxy against amino groups in 5. The antibacterial activity of the compounds 6a and 6c is directed against some gramnegative organisms, i.e. E. coli, Klebsiella spp. and Proteus spp., with MIC values and ED50 values which do not exceed those of the corresponding pyrido[2,3-b]pyrazine-1,4-dioxides.