16206-70-5

Basic information

• Product Name: (14α)-7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol
• Synonyms: (14α)-7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol;trans-Codeine
• CAS NO: 16206-70-5
• Molecular Formula: C₁₈H₂₁NO₃
• Molecular Weight: 299.36
• Mol File: 16206-70-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 98-102 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 462.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• PKA: 13.40±0.20(Predicted)
• CAS DataBase Reference: (14α)-7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (14α)-7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol(16206-70-5)
• EPA Substance Registry System: (14α)-7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol(16206-70-5)

Safety Data

• Hazardous Substances Data: 16206-70-5(Hazardous Substances Data)

Upstream product

• 467-08-3 6β-chloro-4,5α-epoxy-3-methoxy-17-methyl-morphin-7-ene 
• 16206-72-7 4,5α-epoxy-3-methoxy-17-methyl-8α-(toluene-4-sulfonyloxy)-(14α)-morphinan-6α-ol 
• 466-96-6 allopseudocodeine 

Downstream Products

• 57-27-2 (+/-)-morphine 
• 120094-77-1 isocodeine benzyl dithiocarbonate 
• 466-95-5 8β-chloro-4,5α-epoxy-3-methoxy-17-methyl-morphin-6-ene 
• 28613-69-6 4,5α-epoxy-3-methoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-(14α)-morphin-7-ene 
• 115-37-7 thebaine 
• 63783-54-0 O-acetylisocodeine 
• 52-28-8 codeine phosphate 

Relevant articles and documents

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A total synthesis of (±)-codeine by 1,3-dipolar cycloaddition

Nitrone cycloaddition on a dearomatized bicyclic phenol enabled the facile construction of the correctly configured phenanthrene skeleton of codeine. Further steps yielded allopseudocodeine in a completely diastereoselective manner and finally (±)-codeine by allylic transposition through the hydrolysis of chlorocodides.

On the analysis and the stability of codeine phosphate. Part 1: Detection and determination of codeine in the presence of degradation products

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Synthesis of B-C trans-morphine.

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