52-28-8 Usage
Chemical Properties
White to Off-White Solid
Uses
Present in opium from 0.7% to 2.5%, depending on the source. Weak narcotic analgesic, perhaps due to conversion to morphine, with minimal hypnotic properties; potent antitussive.
Controlled substance (opiate)
General Description
Colorless small crystals or white powder. Odorless. Bitter taste. Solutions are acid to litmus. pH (4% solution) 4.2-5.
Air & Water Reactions
Water soluble.
Reactivity Profile
codeine phosphate is sensitive to exposure to light. . Materials that are acidic salts are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Fire Hazard
Flash point data for codeine phosphate are not available; however, codeine phosphate is probably combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 52-28-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 52-28:
(4*5)+(3*2)+(2*2)+(1*8)=38
38 % 10 = 8
So 52-28-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H21NO3.H3O4P/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;1-5(2,3)4/h3-6,11-13,17,20H,7-9H2,1-2H3;(H3,1,2,3,4)/p-3/t11-,12+,13-,17-,18-;/m0./s1
52-28-8Relevant articles and documents
PROCESS FOR THE PRODUCTION OF OPIATES
-
Page/Page column 4-5, (2008/06/13)
A morphine component, e.g., a concentrate of poppy straw, is converted into codeine in high yield and high purity and in a highly controlled manner. The conversion process involves the following steps: (a) providing a solution or suspension of a morphine component in an inert solvent or a mixture of solvents; (b) methylating the resultant solution or suspension with a methylating agent in the presence of an alkaline ingredient; and (c) recovering the resultant codeine as the free base or as a salt.