52-28-8 Usage
Uses
Used in Pharmaceutical Industry:
Codeine phosphate is used as a pain reliever for mild to moderate pain due to its weak narcotic analgesic properties. It is particularly useful in cases where stronger opioids may not be necessary or desired.
Used in Cough Suppressants:
Codeine phosphate is used as an antitussive agent in the pharmaceutical industry to suppress coughs. Its potent cough-suppressing effects make it a popular choice for treating dry, non-productive coughs.
Used in Combination Medications:
Codeine phosphate is often used in combination with other medications, such as acetaminophen or ibuprofen, to enhance the pain-relieving effects while minimizing the risk of side effects associated with higher doses of codeine.
Used in Veterinary Medicine:
In addition to its use in human medicine, codeine phosphate is also utilized in veterinary medicine for the management of pain and cough suppression in animals. Its effectiveness and safety profile make it a suitable option for treating various conditions in veterinary patients.
Air & Water Reactions
Water soluble.
Reactivity Profile
codeine phosphate is sensitive to exposure to light. . Materials that are acidic salts are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Fire Hazard
Flash point data for codeine phosphate are not available; however, codeine phosphate is probably combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 52-28-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 52-28:
(4*5)+(3*2)+(2*2)+(1*8)=38
38 % 10 = 8
So 52-28-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H21NO3.H3O4P/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;1-5(2,3)4/h3-6,11-13,17,20H,7-9H2,1-2H3;(H3,1,2,3,4)/p-3/t11-,12+,13-,17-,18-;/m0./s1
52-28-8Relevant academic research and scientific papers
PROCESS FOR THE PRODUCTION OF OPIATES
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Page/Page column 6, (2008/06/13)
A morphine component, e.g., a concentrate of poppy straw, is converted into codeine in high yield and high purity and in a highly controlled manner. The conversion process involves the following steps: (a) providing a solution or suspension of a morphine component in an inert solvent or a mixture of solvents; (b) methylating the resultant solution or suspension with a methylating agent in the presence of an alkaline ingredient; and (c) recovering the resultant codeine as the free base or as a salt.
Process for the production of opiates
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Page/Page column 10, (2008/06/13)
A morphine component, e.g., a concentrate of poppy straw, is converted into codeine in high yield and high purity and in a highly controlled manner. The conversion process involves the following steps: (a) providing a solution or suspension of a morphine component in an inert solvent or a mixture of solvents; (b) methylating the resultant solution or suspension with a methylating agent in the presence of an alkaline ingredient; and (c) recovering the resultant codeine as the free base or as a salt.
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