1620644-76-9

Upstream product

• 2107-69-9 5,6-dimethoxy-1-indanone 
• 1620645-94-4 4-chloromethyl-N,N-diisopropylnicotinamide hydrochloride 
• 77924-03-9 N,N-diisopropyl-4-formyl-3-pyridinecarboxamide 
• 77924-01-7 N,N-diisopropylnicotinamide 
• 83-33-0 inden-1-one 
• 1620646-01-6 4-(5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl-N,N-diisopropylnicotinamide 
• 100-39-0 benzyl bromide 
• 1620645-99-9 ethyl 2-(3-diisopropylcarbamoylpyridin-4-yl)methyl-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate 
• 53295-44-6 5,6-(dimethoxy)-2-(ethoxycarbonyl)-indan-1-one 

Relevant academic research and scientific papers

OXIDISABLE PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS ANTI-ALZHEIMER AGENTS

A compound of formula (I) in which the dotted lines indicate the presence of at least one double bond; n = 0 to 4; R3 and R4 are H, or when n = 1, R3 and R4 can also form together a double bond between the carbon atoms, and m = 0, 1 or 2, Z is CH or N or Z is C and - CHR3- is =CH- linked by the double bond to cyclopentanone; or - (-)m- is absent, and Z is NH, >N-alkyl, >N-phenyl, >N-benzyl or >N heteroaryl; R8 is alkyl, aryl or heteroaryl which can be optionally substituted; EWG represents an electron withdrawing group selected from the group comprising COOR, COSR, CONRR', CN, COR, CF3, SOR, SO2R, SONRR', SO2NRR', NO2, halogen, heteroaryl; and the pharmaceutical salts and stereisomers thereof. The compounds of formula (I) are potent in the treatment of neurodegenerative diseases such as Alzheimer's disease.

Oxidisable pyridine derivatives, their preparation and use as anti-Alzheimer agents

A compound of the formula (I) in which the dotted lines indicate the presence of at least one double bond; n = 0 to 4; R3 and R4 are H, or when n = 1, R3 and R4 can also form together a double bond between the carbon atoms, and m = 0, 1 or 2, Z is CH or N or Z is C and -CHR3- is =CH- linked by the double bond to the cyclopentanone; or -(-)m- is absent, and Z is NH, >N-alkyl, >N-phenyl, >N-benzyl or >N-heteroaryl; R8 is alkyl, aryl or heteroaryl which can be optionally substituted; EWG represents an electron withdrawing group selected from the group comprising COOR, COSR, CONRR', CN, COR, CF3, SOR, SO2R, SONRR', SO2NRR', NO2, halogen, heteroaryl; and the pharmaceutical salts or tautomers thereof. The compounds of formula (I) are potent in the treatment of neurodegenerative diseases such as Alzheimer's disease.