1620682-53-2Relevant academic research and scientific papers
Synthesis of Indolines and Derivatives by Aza-Heck Cyclization
Xu, Feiyang,Korch, Katerina M.,Watson, Donald A.
, p. 13448 - 13451 (2019)
For the first time, an aza-Heck cyclization that allows the preparation of indoline scaffolds is described. Using N-hydroxy anilines as electrophiles, which can be easily accessed from the corresponding nitroarenes, this method provides indolines bearing pendant functionality and complex ring topologies. Synthesis of challenging indolines, such as those bearing fully substituted carbon atoms at C2, is also possible using this method.
Palladium(0)-catalyzed intramolecular decarboxylative allylation of ortho nitrobenzoic esters
Hossian, Asik,Singha, Shantanu,Jana, Ranjan
, p. 3934 - 3937 (2014/08/18)
A Pd/Ag bimetallic system has been developed for the decarboxylative allylation of ortho-nitrobenzoic esters in an intramolecular fashion. In contrast to the typical sp2-sp3 cross-coupling approach which requires air and moisture sensitive preformed organometallic reagents, we provide an alternative route to the synthesis of ortho-allyl nitroarenes from the corresponding ortho-nitrobenzoic acid derivatives. The reaction proceeds through a mechanistically distinct decarboxylative metalation pathway. A cooperative reactivity of palladium and silver is crucial for the reaction outcome.
