1620809-53-1Relevant academic research and scientific papers
Synthesis of Azidoanilines by the Buchwald-Hartwig Amination
Hosoya, Takamitsu,Sakata, Yuki,Yoshida, Suguru
, p. 15674 - 15688 (2021/11/16)
We report a Buchwald-Hartwig amination compatible with azido functionality. Treatment of azidoaryl iodides and amines with fourth-generation Buchwald precatalyst coordinated by CPhos and sodium tert-butoxide in 1,4-dioxane at 50 °C afforded the corresponding azidoanilines while leaving the azido groups intact. The method showed a broad substrate scope and was applicable to the synthesis of diazido compounds as photoaffinity probe candidates of pharmaceutical amines and multiazido platform molecules.
Synthesis of diverse 3-azido-5-(azidomethyl)benzene derivatives via formal C-H azidation and functional group-selective transformations
Nishiyama, Yoshitake,Misawa, Yoshihiro,Hazama, Yuki,Oya, Kazuhiro,Yoshida, Suguru,Hosoya, Takamitsu
, p. 1053 - 1072 (2019/07/31)
3-Azido-5-(azidomethyl)benzene derivatives are useful compounds for preparing diverse bistriazole compounds and photoaffinity probes for target identification of bioactive compounds. To more easily synthesize a diverse range of diazido compounds, a facile
Formal C-H-azidation-based shortcut to diazido building blocks for the versatile preparation of photoaffinity labeling probes
Yoshida, Suguru,Misawa, Yoshihiro,Hosoya, Takamitsu
supporting information, p. 3991 - 3995 (2014/07/08)
Short synthetic routes to diazido building blocks with different connectable groups were established on the basis of the sequential iridium-catalyzed C-H borylation and copper-catalyzed azidation of 1,3-disubstituted benzenes, followed by diverse azido-fr
