1620835-96-2Relevant academic research and scientific papers
Asymmetric Friedel-Crafts reactions of N-tert-butylsulfinyl-3,3,3- trifluoroacetaldimines: General access to enantiomerically pure indoles containing a 1-amino-2,2,2-trifluoroethyl group
Wu, Lingmin,Xie, Chen,Mei, Haibo,Soloshonok, Vadim A.,Han, Jianlin,Pan, Yi
, p. 7677 - 7681 (2014)
We have demonstrated that 3,3,3-trifluoroacetaldimine (S)-1 easily reacts with indole derivatives under Friedel-Crafts reactions to provide reliable and generalized access to biologically interesting compounds containing the CF 3CH(NH2)- pharmacophoric group. The reactions proceed with high rates and generally excellent yields (>90%) and stereochemical outcomes (99:1 dr).
