3377-71-7Relevant articles and documents
An efficient method for the N-debenzylation of aromatic heterocycles
Rao, T. Srinivasa,Pandey, Pramod S.
, p. 3121 - 3127 (2004)
The N-debenzylation of aromatic heterocycles such as substituted pyrroles and indoles, having functional groups like ester, amide, halo, and nitrile, by using sodium in liquid ammonia in the presence of t-BuOH at -78°C cleanly affords N-debenzylated aromatic heterocycles in good yields.
Regioselective 2-alkylation of indoles with α-bromo esters catalyzed by Pd/P,P=O system
Tian, Wei,Li, Bowen,Tian, Duanshuai,Tang, Wenjun
supporting information, p. 197 - 200 (2021/08/13)
A palladium-catalyzed 2-alkylation of indoles with α-bromo esters is developed by employing a P,P=O ligand. The method features excellent regioselectivities, mild reaction conditions, and good functional group compatibility. The employment of the P,P=O ligand as well as 4? molecular sieves were crucial for the success of the transformation. Mechanistic studies indicate the reaction proceed through a radical pathway.
METHOD FOR PRODUCING AROMATIC COMPOUND USING HETEROGENEOUS NOBLE METAL CATALYST
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Paragraph 0038-0041; 0053-0056, (2021/09/15)
PROBLEM TO BE SOLVED: To provide a technique for synthesizing aromatic compound such as indole by dehydrogenation reaction that is low in manufacturing cost, and a green technique that is low in environmental impact. SOLUTION: Provided is a method for pro
Three-component reactions of 3-arylidene-3h-indolium salts, isocyanides and amines
Nguyen, Hung M.,Golantsov, Nikita E.,Golubenkova, Alexandra S.,Rybakov, Victor B.,Voskressensky, Leonid G.
, (2021/05/26)
A multicomponent reaction of isocyanides with aryl(indol-3-yl)methylium salts and amines has been found. A series of aryl(indol-3-yl)acetimidamides was obtained in up to 96% yields. In the case of ethyl isocyanoacetate, the reaction is followed by cyclization to form 3,5-dihydro-4H-imidazol-4-one derivatives.
