1620889-52-2Relevant academic research and scientific papers
Highly efficient heterogeneous synthesis of benzofurans under aqueous condition
Sun, Shi-Xin,Wang, Jun-Jie,Xu, Zi-Jun,Cao, Lu-Ya,Shi, Zi-Fa,Zhang, Hao-Li
, p. 3798 - 3806 (2014/05/20)
Highly efficient organic reactions in water are important for designing environmental-friendly and low cost synthetic processes. Herein, we demonstrate an intermediate-in-water strategy for the heterogeneous synthesis of benzofurans in aqueous media. The cyclization reaction of 2-(phenylethynyl)phenol to 2-phenylbenzofuran cannot proceed in pure water. However, this reaction can be efficiently promoted by the formation of sparingly soluble intermediate in the presence of alkaline. Quantitative conversion of a variety of substrates to benzofuran derivatives has been achieved in the absence of noble metal catalyst. Other remarkable features including easy-isolation and purification of product, along with wide range of functional group tolerance render the methodology promising in the realm of green-synthesis.
