162089-53-4Relevant academic research and scientific papers
New synthetic route of guanidine from trichloroacetamide for tetrodotoxin and its related compounds
Nishikawa, Toshio,Ohyabu, Norio,Yamamoto, Noboru,Isobe, Minoru
, p. 4325 - 4340 (1999)
Trichloroacetamide was transformed into dibenzylguanidinium salt in three steps. Attempted debenzylation was very difficult in the guanidinium form even under high pressure hydrogen and high temperature conditions. On the other hand, the benzyl groups on
Direct Preparation of Guanidine from Trichloroacetamide. A Potentially Important Method to (-)-Tetrodotoxin
Yamamoto, Noboru,Isobe, Minoru
, p. 2299 - 2302 (2007/10/02)
Trichloroacetamides obtained via Overman sigmatropic rearrangement were converted into dibenzyl guanidines.The key step was conversion of carbodiimide intermediate into guanidine by scandium or ytterbium trifluoromethane-sulfonates.This method was a
