222983-12-2Relevant academic research and scientific papers
New synthetic route of guanidine from trichloroacetamide for tetrodotoxin and its related compounds
Nishikawa, Toshio,Ohyabu, Norio,Yamamoto, Noboru,Isobe, Minoru
, p. 4325 - 4340 (2007/10/03)
Trichloroacetamide was transformed into dibenzylguanidinium salt in three steps. Attempted debenzylation was very difficult in the guanidinium form even under high pressure hydrogen and high temperature conditions. On the other hand, the benzyl groups on
