162100-15-4

Basic information

• Product Name: SB 215505
• Synonyms: 6-chloro-5-methyl-N-quinolin-5-yl-2,3-dihydroindole-1-carboxamide
• CAS NO: 162100-15-4
• Molecular Formula: C19H16ClN3O
• Molecular Weight: 337.808
• Mol File: 162100-15-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 600.9°C at 760 mmHg
• Flash Point: 317.2°C
• Appearance: off-white/solid
• Density: 1.385g/cm³
• Vapor Pressure: 2.13E-14mmHg at 25°C
• Refractive Index: 1.725
• Storage Temp.: 2-8°C
• Solubility: DMSO: ~11 mg/mL at 60 °C, soluble
• CAS DataBase Reference: SB 215505(CAS DataBase Reference)
• NIST Chemistry Reference: SB 215505(162100-15-4)
• EPA Substance Registry System: SB 215505(162100-15-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 162100-15-4(Hazardous Substances Data)

Usage

Uses

SB-215505 is a selective 5-HT2B serotonin receptor antagonist.

InChI:InChI=1/C19H16ClN3O/c1-12-10-13-7-9-23(18(13)11-15(12)20)19(24)22-17-6-8-21-16-5-3-2-4-14(16)17/h2-6,8,10-11H,7,9H2,1H3,(H,21,22,24)

Upstream product

• 611-34-7 5-Aminoquinoline 
• 162100-44-9 6-chloro-5-methyl-2,3-dihydro-1H-indole 

Relevant articles and documents

PYRIDYLCARBAMOYL INDOLINES

Compounds of formula (I), processes for their preparation and their use in medicine are disclosed: STR1 wherein: P represents phenyl, a quinoline or isoquinoline residue, or a 5-membered or 6-membered aromatic heterocyclic ring containing up to three heteroatoms selected from nitrogen, oxygen or sulphur;R 1 is hydrogen, C. sub.1-6 alkyl, halogen, CF 3, NR 7 R 8 or OR 9 where R. sup.7, R 8 and R 9 are independently hydrogen, C 1-6 alkyl or arylC 1-6 alkyl;R 2 is hydrogen or C. sub.1-6 alkyl; R 3 is C 1-6 alkyl;n is 0 to 3;m is 0 to 4; and R. sup.4 groups are independently C 1-6 alkyl optionally substituted by one or more halogen atoms, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-6 alkyl, C. sub.1-6 alkylthio, C. sub.3-6 cycloalkylthio, C 3-6 cycloalkylC 1 C 6 alkylthio, halogen, nitro, CF 3, OCF 3, SCF 3, SO. sub.2 CF 3, SO. sub.2 F, formyl, C 2-6 alkanoyl, cyano, optionally substituted phenyl or thienyl, NR 7 R 8, CONR 7 R. sup.8, or OR 9 where R. sup.7, R 8 and R 9 are as defined for R 1, CO 2 R 10 where R 10 is hydrogen or C 1-6 alkyl.