162110-31-8

Basic information

• Product Name: 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-5-methyl-6-oxo-8-(phenylmethoxy)-, 1,1-dimethylethyl ester
• Synonyms: DM 236
• CAS NO: 162110-31-8
• Molecular Formula: C24H25 N3 O4
• Molecular Weight: 419.48
• Mol File: 162110-31-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-5-methyl-6-oxo-8-(phenylmethoxy)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-5-methyl-6-oxo-8-(phenylmethoxy)-, 1,1-dimethylethyl ester(162110-31-8)
• EPA Substance Registry System: 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-5-methyl-6-oxo-8-(phenylmethoxy)-, 1,1-dimethylethyl ester(162110-31-8)

Safety Data

• Hazardous Substances Data: 162110-31-8(Hazardous Substances Data)

Upstream product

• 130477-45-1 7-methoxy-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5-(1H)-dione 
• 2769-72-4 tert-Butyl isocyanoacetate 
• 162110-26-1 7-(benzyloxy)-4-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 6705-03-9 2-Amino-5-methoxybenzoic acid 
• 37795-77-0 6-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione 
• 162110-24-9 7-hydroxy-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5-(1H)-dione 
• 3415-35-8 4-methyl-3H-1,4-benzodiazepine-2,5-(1H,4H)-dione 
• 84377-96-8 7-nitro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5-(1H)-dione 
• 147964-21-4 7-amino-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5-(1H)-dione 

Relevant articles and documents

The development of potential new fluorine-18 labelled radiotracers for imaging the GABAA receptor

Positron emission tomography (PET) using the tracer [11C] Flumazenil has shown changes in the distribution and expression of the GABA A receptor in a range of neurological conditions and injury states. We aim to develop a fluorine-18 labelled PET agent with comparable properties to [11C]Flumazenil. In this study we make a direct comparison between the currently known fluorine-18 labelled GABAA radiotracers and novel imidazobenzodiazepine ligands. A focussed library of novel compound was designed and synthesised where the fluorine containing moiety and the position of attachment is varied. The in vitro affinity of twenty-two compounds for the GABAA receptor was measured. Compounds containing a fluoroalkyl amide or a longer chain ester group were eliminated due to low potency. The fluorine-18 radiochemistry of one compound from each structural type was assessed to confirm that an automated radiosynthesis in good yield was feasible. Eleven of the novel compounds assessed appeared suitable for in vivo assessment as PET tracers.

8-Alkylamino and 8-Alkoxy Derivatives of Imidazo[1,5-a][1,4]benzodiazepine t-Butyl Esters: Novel GABAA/Benzodiazepine Receptor Ligands

Novel 8-alkylamino and 8-alkoxy substituted imidazo[1,5-a][1,4]benzodiazepine t-butyl esters have been synthesized and their potencies as benzodiazepine receptors (BZR) ligands evaluated. These new compounds exhibit a broad range of affinities at "diazepa