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CAS

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1621160-30-2

N‐(2‐oxo‐1,2‐dihydro‐[5,6‐D2]pyrimidin‐4‐yl)benzamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1621160-30-2 Structure

  • Basic information

    1. Product Name: N‐(2‐oxo‐1,2‐dihydro‐[5,6‐D2]pyrimidin‐4‐yl)benzamide
    2. Synonyms: N‐(2‐oxo‐1,2‐dihydro‐[5,6‐D2]pyrimidin‐4‐yl)benzamide
    3. CAS NO:1621160-30-2
    4. Molecular Formula:
    5. Molecular Weight: 217.195
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1621160-30-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N‐(2‐oxo‐1,2‐dihydro‐[5,6‐D2]pyrimidin‐4‐yl)benzamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N‐(2‐oxo‐1,2‐dihydro‐[5,6‐D2]pyrimidin‐4‐yl)benzamide(1621160-30-2)
    11. EPA Substance Registry System: N‐(2‐oxo‐1,2‐dihydro‐[5,6‐D2]pyrimidin‐4‐yl)benzamide(1621160-30-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1621160-30-2(Hazardous Substances Data)

1621160-30-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1621160-30-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,1,1,6 and 0 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1621160-30:
(9*1)+(8*6)+(7*2)+(6*1)+(5*1)+(4*6)+(3*0)+(2*3)+(1*0)=112
112 % 10 = 2
So 1621160-30-2 is a valid CAS Registry Number.

1621160-30-2Upstream product

1621160-30-2Relevant articles and documents

Synthesis and biological evaluation of deuterated sofosbuvir analogs as HCV NS5B inhibitors with enhanced pharmacokinetic properties

Ao, Wangwei,Ma, Xueqin,Lin, Youping,Wang, Xiaojing,Song, Wei,Wang, Qinglin,Zhang, Xiquan,Xu, Hongjiang,Zhang, Yinsheng

, p. 215 - 229 (2019)

A series of deuterated sofosbuvir analogs were designed and prepared with the aim of improving their pharmacokinetic properties. The devised synthetic routes allow for site-selective deuterium incorporation with high levels of isotopic purity. As expected, the deuterated analogs (37-44) are as efficacious as sofosbuvir when tested in vitro inhibition of viral replication (replicon) assays. Compared with sofosbuvir, deuterated analog 40 displays improved in vivo pharmacokinetics profiles in rats and dogs in terms of the metabolite and the prodrug. The Cmax and area under the curve (AUC) of 40 in dogs were increased by 3.4- and 2.7-fold, respectively. Due to the enhanced pharmacokinetic properties and the great synthetic advantage of an inexpensive deuterium source (D2O) for 40, it was chosen for further investigation.

Deuterated nucleoside derivative

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Paragraph 0180; 0181; 0184; 0185, (2016/10/07)

The present invention relates to deuterated nucleoside derivative, particularly to a compound having a structure represented by a formula I or a pharmaceutically acceptable salt thereof. According to the present invention, the compound represented by the formula I has excellent pharmacokinetic properties and is expected to reduce the clinical dose so as to reduce the treatment and benefit more patients. The formula I is defined in the specification.

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