1621167-79-0

Basic information

• Product Name: 5-bromo-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one
• Synonyms: 5-bromo-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one
• CAS NO: 1621167-79-0
• Molecular Weight: 342.192
• Mol File: 1621167-79-0.mol

Chemical Properties

• CAS DataBase Reference: 5-bromo-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one(1621167-79-0)
• EPA Substance Registry System: 5-bromo-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one(1621167-79-0)

Safety Data

• Hazardous Substances Data: 1621167-79-0(Hazardous Substances Data)

Upstream product

• 6738-06-3 phenylethynylmagnesium bromide 
• 2058-72-2 5-bromo-1-methyl-1H-indole-2,3-dione 
• 536-74-3 phenylacetylene 

Relevant articles and documents

Stereoselective and Regioselective Assembly of Spirooxindole [2,1-b]furan Motifs through a Tandem Friedel–Crafts Alkylation/5-exo-dig-Cyclization

3-Alkynyl-3-OBoc (Boc = tert-butoxycarbonyl) oxindole derivatives underwent a CuII-mediated stereo- and regioselective Friedel–Crafts alkylation/5-exo-dig-cyclization with 2-naphthols or cyclic 1,3-diketones. This gave spirooxindole [2,1-b]furan motifs in good to excellent yields under ambient conditions, and the process has a wide substrate scope.

Synthesis of 3-ethynyl-3-hydroxy-2-oxindoles and 3-hydroxy-3-(indol-3-yl) indolin-2-ones using CuWO4 nanoparticles as recyclable heterogeneous catalyst in aqueous medium

A simple method for the direct activation of phenyl acetylenes (spC-H activation) and selective synthesis of 3-hydroxy-3-(indol-3-yl) indolin-2-ones and 3,3′-bis(indolyl)indolin-2-ones (via Friedel-Crafts alkylation reaction) is reported in presence of Cu

Catalytic C-H activation of arylacetylenes: A fast assembly of 3-(arylethynyl)-3-hydroxyindolin-2-ones using CuI/DBU

A highly efficient and atom-economic methodology has been developed for the synthesis of 3-(arylethynyl)-3-hydroxyindolin-2-ones from isatins by C-H activation of arylacetylenes using a catalytic quantity of copper(I) iodide (5 mol%) and DBU (20 mol%) at 25°C, affording the products in excellent yields in very short reaction time (5 min).