2058-72-2

Usage

Uses

Used in Pharmaceutical Research:
5-Bromo-1-methylisatin is used as a building block in the synthesis of heterocyclic compounds for pharmaceutical research. Its unique structure and properties make it a valuable component in the development of new drugs.
Used in Medicinal Chemistry:
5-Bromo-1-methylisatin is used as a versatile chemical in medicinal chemistry, where it contributes to the discovery and design of novel therapeutic agents.
Used in Organic Synthesis:
5-Bromo-1-methylisatin is used as a key intermediate in various organic synthesis reactions, enabling the creation of a wide range of chemical products.
Used in Anticancer Research:
5-Bromo-1-methylisatin is studied for its potential as an anti-cancer agent, with research exploring its effects on cancer cells and its possible role in cancer treatment.
Used in Antimicrobial Applications:
5-Bromo-1-methylisatin has demonstrated antimicrobial properties in some studies, making it a candidate for use in the development of new antimicrobial agents.
Used in Anti-inflammatory Research:
5-Bromo-1-methylisatin has also shown anti-inflammatory properties, which could lead to its application in the development of treatments for inflammatory conditions.

InChI:InChI=1/C9H6BrNO2/c1-11-7-3-2-5(10)4-6(7)8(12)9(11)13/h2-4H,1H3

Upstream product

• 35452-54-1 4’-bromo-N-methylformanilide 

Downstream Products

• 500028-12-6 1-methyl-5-[4-(4-phenoxy-benzoyl)-phenyl]-1H-indole-2,3-dione 
• 665000-40-8 C₁₅H₁₀BrN₅OS 
• 666819-45-0 5-bromo-1,1'-dimethyl-3-(1-methyl-1H-indole-3-yl)-3,3'-biindolin-2-one 
• 486994-31-4 (S)-5-bromo-3-hydroxy-1-methyl-3-(2-oxo-2-phenylethyl)indol-2-one 
• 1214750-12-5 (S)-5-bromo-3-(4-(dimethylamino)-2-methoxyphenyl)-3-hydroxy-1-methylindol-2-one 
• 1214750-35-2 (S)-5-bromo-3-(4-(diethylamino)-2-hydroxyphenyl)-3-hydroxy-1-methylindol-2-one 
• 1219433-06-3 10'-amino-5-bromo-1,2-dihydro-1-methyl-2,7'-dioxospiro[3H-indole-3,8'(7H,8H)-phenaleno[1,2-b]pyran]-9'-carbonitrile 
• 1221252-27-2 3-(5-amino-1,3-diphenyl-1H-pyrazol-4-yl)-5-bromo-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-1-methylindolin-2-one 
• 1253047-31-2 N'-(5-bromo-1-methyl-2-oxoindolin-3-ylidene)-1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbohydrazide 
• 1217110-04-7 5-bromo-5'-(2-hydroxybenzoyl)-1-methyl-1',3'-diphenyl-5',7'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-b]pyridine]-2,6'(1'H)-dione 
• 1221252-35-2 C₃₉H₃₀BrN₇O 
• 1310937-76-8 2-(5-bromo-3-(4-(dimethylamino)phenyl)-1-methyl-2-oxoindolin-3-yl)-1H-indene-1,3(2H)-dione 
• 1214750-18-1 (R)-3-allyl-5-bromo-3-hydroxy-1-methylindolin-2-one 
• 1360651-62-2 (2R,4S)-5'-bromo-4-((2-methoxyphenyl)dimethylsilyl)-1'-methyl-4,5-dihydro-3H-spiro[furan-2,3'-indolin]-2'-one 

Relevant academic research and scientific papers

Transformations of N-arylpropiolamides to indoline-2,3-diones and acids via C≡C triple bond oxidative cleavage and C(sp2)–H functionalization

A new palladium-catalyzed oxidative conversion of N-arylpropiolamides and H2O to various indoline-2,3-diones and acids through the C≡C triple bond cleavage and C(sp2)–H functionalization is described, which is promoted by a cooperative action of catalytic CuBr2, 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) and O2. The method provides a practical tool for transformations of alkynes by means of a C–H functionalization strategy, which enables the formation of one C–C bond and multiple C–O bonds in a single reaction with high substrates compatibility and excellent functional group tolerance.

Carbenes from Vilsmeier reagents by the action of bases in POCl3; The umpolung of Vilsmeier reagents

When para-substituted N-methylformanilides are treated in POCl3 with a base, the corresponding Vilsmeier reagent formed undergoes ready deprotonation to give an amino-chlorocarbene from which a range of products derive; a carba- moyl chloride, N-methylisatins, dimers ? [1,2-dichloro-1,2- bis(N-methyl-N-arylamino)ethenes], trimers ? [5,10-dimethyl- 11-(N-methyl-N-arylamino)-10H-indolo[3,2-b]quinolinium and 5,10-dimethyl-10H-indolo[3,2-b]quinolinium salts] and tetramers ? [1,1′-dimethyl-3,3′-bis(N-methyl-N-arylamino)-2,2-biindolyl] are isolated, depending upon the base used and the para-substituent.