1621342-99-1

Basic information

• Product Name: 2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)butanamide
• Synonyms: 2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)butanamide
• CAS NO: 1621342-99-1
• Molecular Weight: 585.746
• Mol File: 1621342-99-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)butanamide(1621342-99-1)
• EPA Substance Registry System: 2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)butanamide(1621342-99-1)

Safety Data

• Hazardous Substances Data: 1621342-99-1(Hazardous Substances Data)

Upstream product

• 19841-73-7 4-(Diphenylmethyl)piperidine 
• 1621341-94-3 2-bromo-4-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)butanamide 
• 85-44-9 phthalic anhydride 
• 3130-75-4 4-phthalimidobutyric acid 
• 39257-85-7 C₁₂H₉BrClNO₃ 
• 35197-64-9 2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid 

Downstream Products

• 1621342-90-2 4-amino-2-(4-benzhydrylpiperidin-1-yl)-N-(4-methylbenzyl)butanamide 

Relevant articles and documents

Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides

Six series of 2-substituted 4-aminobutanamide derivatives were synthesized and evaluated for their ability to inhibit GABA transport proteins mGAT1-4 stably expressed in HEK-293 cell lines. The pIC50 values determined were in the range 4.23-5.23. Two compounds (15b and 15c) were selected for further in vitro studies. These compounds were also subjected to preliminary behavioral studies to evaluate their anticonvulsant, antidepressant-like, and antinociceptive activities in mice. Their influence on motor coordination was also assessed. We report that, among a spectrum of in vivo activities, both 15b and 15c displayed significant activity against pentylenetetrazole (PTZ)-induced seizures.