19841-73-7

Basic information

• Product Name: 4-(diphenylmethyl)piperidine
• Synonyms: 4-(diphenylmethyl)piperidine
• CAS NO: 19841-73-7
• Molecular Formula: C₁₈H₂₁N
• Molecular Weight: 251.36604
• EINECS: 243-365-3
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 19841-73-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 384.53°C (rough estimate)
• Flash Point: 197.2°C
• Appearance: /
• Density: 0.8635 (rough estimate)
• Vapor Pressure: 3.39E-06mmHg at 25°C
• Refractive Index: 1.5320 (estimate)
• CAS DataBase Reference: 4-(diphenylmethyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(diphenylmethyl)piperidine(19841-73-7)
• EPA Substance Registry System: 4-(diphenylmethyl)piperidine(19841-73-7)

Safety Data

• Hazardous Substances Data: 19841-73-7(Hazardous Substances Data)

Usage

Chemical Properties

White solid.Difficultly soluble in water; readily soluble in dilute acids; moderately soluble in organic solvents.

Uses

4-Diphenylmethylpiperidine, is an intermediate in the synthesis of more complex pharmaceutical and biologically active compounds. It can be used in the synthesis of diphenyl lactam derivatives as N-type calcium channel blockers.

InChI:InChI=1/C18H21N/c1-3-7-15(8-4-1)18(16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17-19H,11-14H2

Upstream product

• 3678-72-6 diphenyl-4-pyridylmethane 
• 50706-57-5 4-(diphenylmethylene)piperidine 
• 305794-67-6 1-t-butoxycarbonyl-4-(hydroxydiphenyl)methylpiperidine 
• 86-29-3 Diphenylacetonitrile 
• 626-61-9 4-Chloropyridine 
• 164650-64-0 N-(tert-butoxycarbonyl)-4-[hydroxy(diphenyl)methyl]piperidine 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 1126-09-6 4-carbethoxypiperidine 
• 861014-89-3 3-benzhydryl-1,5-dibromo-pentane 
• 115-46-8 C₁₈H₂₁NO 

Downstream Products

• 102654-88-6 N-(4-benzhydryl-piperidinomethyl)-succinimide 
• 72964-02-4 4-(diphenylmethyl)-1-piperidinecarbothioaldehyde 
• 72964-09-1 4-(diphenylmethyl)-1-piperidinemethanimine hydrochloride 
• 60284-70-0 1-[4-[3-[4-(Diphenylmethyl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone oxalate 
• 89656-22-4 [1-(4-Benzhydryl-piperidin-1-yl)-meth-(E)-ylidene]-tert-butyl-amine 
• 86727-25-5 1-benzyl-4(diphenylmethyl)piperidine 
• 94916-53-7 3-(4-diphenylmethylpiperidin-1-yl)propionitrile 
• 60284-64-2 4-(α-Phenyl)benzylpiperidine-1-carboxanilide 
• 64358-93-6 1-[(4-nitrophenyl)methyl]-4-(diphenylmethyl)piperidine 
• 305794-68-7 C₂₉H₃₇N₃O₂ 
• 1621342-99-1 2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)butanamide 

Relevant articles and documents

Synthesis and anticancer evaluation of 6-azacyclonol-2,4,6-trimethylpyridin-3-ol derivatives: M3 muscarinic acetylcholine receptor-mediated anticancer activity of a cyclohexyl derivative in androgen-refractory prostate cancer

We recently reported 2,4,5-trimethylpyridin-3-ol with C(6)-azacyclonol, whose code name is BJ-1207, showing a promising anticancer activity by inhibiting NOX-derived ROS in A549 human lung cancer cells. The present study was focused on structural modification of the azacyclonol moiety of BJ-1207 to find a compound with better anticancer activity. Ten new compounds (3A–3J) were prepared and evaluated their inhibitory actions against proliferation of eighteen cancer cell lines as a primary screening. Among the ten derivatives of BJ-1207, the effects of compounds 3A and 3J on DU145 and PC-3, androgen-refractory cancer cell lines (ARPC), were greater than the parent compound, and compound 3A showed better activity than 3J. Antitumor activity of compound 3A was also observed in DU145-xenografted chorioallantoic membrane (CAM) tumor model. In addition, the ligand-based target prediction and molecular docking study using DeepZema server showed compound 3A was a ligand to M3 muscarinic acetylcholine receptor (M3R) which is overexpressed in ARPC. Carbachol, a muscarinic receptor agonist, concentration dependently increased proliferation of DU145 in the absence of serum, and it also activated NADPH oxidase (NOX). The carbachol-induced proliferation and NOX activity was significantly blocked by compounds 3A in a concentration-dependent manner. This finding might become a new milestone in the development of pyridinol-based anti-cancer agents against ARPC.

NEW HETEROCYCLIC COMPOUNDS

The invention provides new heterocyclic compounds having the general formula (IA) wherein A, L, X, Y, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Synthesis and SAR of selective small molecule neuropeptide y Y2 receptor antagonists

Highly potent and selective small molecule neuropeptide Y Y2 receptor antagonists are reported. The systematic SAR exploration of a hit molecule N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide, identified from HTS, led to the discovery of highly potent NPY Y2 antagonists 16 (CYM 9484) and 54 (CYM 9552) with IC50 values of 19 nM and 12 nM respectively.