1621432-05-0

Basic information

• Product Name: 6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine
• Synonyms: 6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine
• CAS NO: 1621432-05-0
• Molecular Weight: 397.5
• Mol File: 1621432-05-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine(1621432-05-0)
• EPA Substance Registry System: 6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine(1621432-05-0)

Safety Data

• Hazardous Substances Data: 1621432-05-0(Hazardous Substances Data)

Upstream product

• 1621431-95-5 C₁₅H₉N₃O₂S 
• 136-95-8 2-amino-benzthiazole 
• 1621432-63-0 2-(benzo[d]imidazo[2,1-b]thiazol-2-yl)aniline 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 552-89-6 2-nitro-benzaldehyde 
• 253684-24-1 1-(2,2-dibromovinyl)-2-nitrobenzene 

Relevant articles and documents

Synthesis of biologically active pyridoimidazole/imidazobenzothiazole annulated polyheterocycles using cyanuric chloride in water

An efficient and mild protocol for rapid access to N-fused polyheterocycles via Pictet-Spengler type 6-endo cyclization using cyanuric chloride in an aqueous reaction medium has been developed. The protocol was successfully applied to a wide range of compounds including aryl/heteroaryl aldehydes (8a-o), ketones (10a-e), an electron-rich metallocene aldehyde (8e) and indoline-2,3-diones (12a-c) using cyanuric chloride (15-20 mol%) with tetra-n-butylammonium bromide (TBAB) (2.0 eq.) as an additive at 80-90 °C to give a good to excellent yield (66-92%) of polyheterocycles. Some of the synthesized compounds were found to exhibit antiplasmodial activity against chloroquine-sensitive (CQ-S) 3D7 and chloroquine-resistant (CQ-R) K1 strains of Plasmodium falciparum. This journal is the Partner Organisations 2014.