16217-10-0

Upstream product

• 16257-57-1 methyl (2S,4R)-4-hydroxy-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate 

Downstream Products

• 1036712-99-8 C₁₇H₂₃NO₆S 
• 1036712-97-6 C₁₅H₁₉NO₆S 
• 1036712-98-7 C₁₆H₂₁NO₆S 
• 1173715-90-6 methyl (2S,4Z)-4-ethoxycarbonylmethylene-1-p-toluenesulfonylpyrrolidine-2-carboxylate 
• 1173715-86-0 methyl (2S,4E)-4-ethoxycarbonylmethylene-1-p-toluenesulfonylpyrrolidine-2-carboxylate 
• 1158716-14-3 methyl 4-cyanomethylpyrrole-2-carboxylate 
• 1173715-92-8 methyl (2S,4Z)-4-cyanomethylene-1-p-toluenesulfonylpyrrolidine-2-carboxylate 
• 1173715-88-2 methyl (2S,4E)-4-cyanomethylene-1-p-toluenesulfonylpyrrolidine-2-carboxylate 
• 1173715-82-6 methyl (2S)-4-methylene-1-p-toluenesulfonylpyrroplidine-2-carboxylate 

Relevant academic research and scientific papers

Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors

A series of novel sulfonyl pyrrolidine derivatives were designed, synthesized and assayed for their inhibitory activities on matrix metalloproteinase 2 (MMP-2) and aminopeptidase N (AP-N). The results showed that these pyrrolidine derivatives exhibited highly selective inhibition against MMP-2 as compared with AP-N. Compounds 6a-d were more potent MMP-2 inhibitors than the positive control LY52. The structure-activity relationships were also briefly discussed.