162204-30-0 Usage
Uses
Used in Pharmaceutical Industry:
5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine is used as an antitumor agent for its potential role in cancer treatment. As a 5'-Desoxycytidine derivative, it may contribute to the development of new therapeutic strategies against various types of cancer.
The compound's specific application reason is its antitumor properties, which make it a valuable candidate for further research and development in the field of oncology. Its chemical structure allows it to potentially interfere with cancer cell growth and proliferation, offering a new avenue for cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 162204-30-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,2,0 and 4 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 162204-30:
(8*1)+(7*6)+(6*2)+(5*2)+(4*0)+(3*4)+(2*3)+(1*0)=90
90 % 10 = 0
So 162204-30-0 is a valid CAS Registry Number.
162204-30-0Relevant articles and documents
Synthesis and biological activity evaluation of cytidine-5′-deoxy-5- fluoro-N-[(alkoxy/aryloxy)] carbonyl-cyclic 2′,3′-carbonates
Jhansi Rani,Raghavendra,Kishore,Nanda Kumar,Hema Kumar,Jagadeeswarareddy
, p. 690 - 696 (2012/09/08)
Capecitabine, an oral prodrug of 5-FU was developed to improve the tumor selectivity and tolerability. To enhance the efficacy of capacitabine, a series of 5′-deoxy-5-fluorocytidine derivatives 5a-e were synthesized. In the present study, we investigated antitumor activity of 5′-deoxy-5- fluorocytidine derivatives both in vivo and in vitro methods. Title compounds were non-mutagenic to Salmonella typhimurium tester strain in Ames test. Compounds 5d and 5e are potent to inhibit the proliferation of NCI-69, PZ-HPV-7, MCF-7 and HeLa cells in MTT assay. In particular, 5d and 5e showed potent antitumor activities against L1210 leukemia cell line. Collectively, these findings suggest that 5d and 5e are more potent anti-cancer compounds than capecitabine.
