162204-30-0

Basic information

• Product Name: 5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine
• Synonyms: [1-(5-Deoxy--D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl]-carbamic Acid 3-Methylbutyl Ester;5'-Deoxy-5-fluoro-N-[(3-methylbutoxy)carbonyl]cytidine;5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine;Capecitabine iMpurity F;Cytidine, 5'-deoxy-5-fluoro-N-[(3-Methylbutoxy)carbonyl]-;5'-Deoxy-5-fluoro-N4-(2-methyl-1-butuloxycarbonyl)cytidine;5'-Deoxy-5-fluoro-N4-(3-methyl-1-butyloxycarbonyl)cytidine;Capecitabine 3-Methylbutyloxy Impurity
• CAS NO: 162204-30-0
• Molecular Formula: C₁₅H₂₂FN₃O₆
• Molecular Weight: 359.3500832
• Product Categories: Bases & Related Reagents;Intermediates;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
• Mol File: 162204-30-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 106-109°C
• Appearance: /
• Density: 1.49±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Methanol (Slightly)
• PKA: 5.44±0.40(Predicted)
• CAS DataBase Reference: 5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine(162204-30-0)
• EPA Substance Registry System: 5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine(162204-30-0)

Safety Data

• Hazardous Substances Data: 162204-30-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 162204-30-0 differently. You can refer to the following data:
1. 5''-Deoxy-5-fluoro-N-[(3-methylbutoxy)carbonyl]cytidine (Capecitabine EP Impurity E) is a 5''-Desoxycytidine derivative and is used as an antitumor agent.
2. 5'-Deoxy-5-fluoro-N-[(3-methylbutoxy)carbonyl]cytidine is 5' Desoxycytidine derivatives are used as antitumor agents.

Upstream product

• 628-50-2 carbonochloridic acid 3-methyl-butyl ester 

Relevant articles and documents

Synthesis and biological activity evaluation of cytidine-5′-deoxy-5- fluoro-N-[(alkoxy/aryloxy)] carbonyl-cyclic 2′,3′-carbonates

Capecitabine, an oral prodrug of 5-FU was developed to improve the tumor selectivity and tolerability. To enhance the efficacy of capacitabine, a series of 5′-deoxy-5-fluorocytidine derivatives 5a-e were synthesized. In the present study, we investigated antitumor activity of 5′-deoxy-5- fluorocytidine derivatives both in vivo and in vitro methods. Title compounds were non-mutagenic to Salmonella typhimurium tester strain in Ames test. Compounds 5d and 5e are potent to inhibit the proliferation of NCI-69, PZ-HPV-7, MCF-7 and HeLa cells in MTT assay. In particular, 5d and 5e showed potent antitumor activities against L1210 leukemia cell line. Collectively, these findings suggest that 5d and 5e are more potent anti-cancer compounds than capecitabine.