628-50-2

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Methylbutyl Chloroformate is used as a key intermediate in the synthesis of various pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Production:
In the agrochemical industry, 3-Methylbutyl Chloroformate is utilized as a precursor in the production of pesticides and other crop protection agents, enhancing agricultural productivity and crop protection.
Used as a Reagent in Organic Synthesis:
3-Methylbutyl Chloroformate is employed as a reagent in organic synthesis processes, particularly for the formation of esters and other organic compounds, facilitating the creation of a wide range of chemical products.
Used in Research and Development:
3-Methylbutyl Chloroformate is utilized in research and development settings for exploring new chemical reactions and synthesizing novel compounds, contributing to advancements in the field of chemistry and related disciplines.

Upstream product

• 75-44-5 phosgene 
• 123-51-3 i-Amyl alcohol 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 1259312-25-8 7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-1-(hydroxymethyl)-3,4-dihydroquinolin-2-(1H )-one 

Downstream Products

• 2050-95-5 diisoamyl carbonate 
• 134542-50-0 (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl isopentyl carbonate 
• 80-46-6 4-t-amylphenol 
• 861579-08-0 (2-hydroxy-phenyl)-carbamic acid isopentyl ester 

Relevant academic research and scientific papers

Prodrugs of NH-acidic compounds

The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

Synthesis and biological activity evaluation of cytidine-5′-deoxy-5- fluoro-N-[(alkoxy/aryloxy)] carbonyl-cyclic 2′,3′-carbonates

Capecitabine, an oral prodrug of 5-FU was developed to improve the tumor selectivity and tolerability. To enhance the efficacy of capacitabine, a series of 5′-deoxy-5-fluorocytidine derivatives 5a-e were synthesized. In the present study, we investigated antitumor activity of 5′-deoxy-5- fluorocytidine derivatives both in vivo and in vitro methods. Title compounds were non-mutagenic to Salmonella typhimurium tester strain in Ames test. Compounds 5d and 5e are potent to inhibit the proliferation of NCI-69, PZ-HPV-7, MCF-7 and HeLa cells in MTT assay. In particular, 5d and 5e showed potent antitumor activities against L1210 leukemia cell line. Collectively, these findings suggest that 5d and 5e are more potent anti-cancer compounds than capecitabine.

Preparation of chloroformates using bis(trichloromethyl)carbonate

The synthesis of eight chloroformates using bis(trichloromethyl) carbonate(BTC) is reported. It has been found that the yields by this BTC method are improved over the earlier phosgene method, and sodium hydroxide is better than pyridine as catalyst for the preparation of phenyl chloroformate.

New radical reactions of S-alkoxycarbonyl xanthates. Total synthesis of (±)-cinnamolide and (±)-methylenolactocin

Irradiation with visible light of S-alkoxycarbonyl xanthates derived from various alcohols gives rise to alkoxycarbonyl radicals with bifurcate reactivity: loss of carbon dioxide leads to deoxygenated derivatives (i.e. alkyl xanthates) whereas intramolecular addition to a suitably located double bond produces lactones; these new reactions were applied to the total synthesis of (±)-cinnamolide and (±)-methylenolactocin.