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628-50-2

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628-50-2 Usage

General Description

3-Methylbutyl chloroformate is a colorless to pale yellow liquid with a pungent odor. It is a chemical compound used in the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in organic synthesis, particularly in the formation of esters and other organic compounds. It is known to be a skin and eye irritant and should be handled with care. 3-Methylbutyl chloroformate can also react violently with water and strong oxidizing agents, and should be stored and handled in a well-ventilated area with appropriate safety precautions.

Check Digit Verification of cas no

The CAS Registry Mumber 628-50-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 628-50:
(5*6)+(4*2)+(3*8)+(2*5)+(1*0)=72
72 % 10 = 2
So 628-50-2 is a valid CAS Registry Number.

628-50-2Relevant articles and documents

Prodrugs of NH-acidic compounds

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Page/Page column 415, (2015/11/16)

The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

Preparation of chloroformates using bis(trichloromethyl)carbonate

Shi, Haibo,Hu, Weixiao,Sun, Yaquan

, p. 708 - 709 (2007/10/03)

The synthesis of eight chloroformates using bis(trichloromethyl) carbonate(BTC) is reported. It has been found that the yields by this BTC method are improved over the earlier phosgene method, and sodium hydroxide is better than pyridine as catalyst for the preparation of phenyl chloroformate.

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