1622208-41-6

Basic information

• Product Name: 3-(3-chloro-4-methylphenyl)-N-cyclopropyl-3H-imidazo[4,5-b]pyridine-2-carboxamide
• Synonyms: 3-(3-chloro-4-methylphenyl)-N-cyclopropyl-3H-imidazo[4,5-b]pyridine-2-carboxamide
• CAS NO: 1622208-41-6
• Molecular Weight: 326.785
• Mol File: 1622208-41-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(3-chloro-4-methylphenyl)-N-cyclopropyl-3H-imidazo[4,5-b]pyridine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-chloro-4-methylphenyl)-N-cyclopropyl-3H-imidazo[4,5-b]pyridine-2-carboxamide(1622208-41-6)
• EPA Substance Registry System: 3-(3-chloro-4-methylphenyl)-N-cyclopropyl-3H-imidazo[4,5-b]pyridine-2-carboxamide(1622208-41-6)

Safety Data

• Hazardous Substances Data: 1622208-41-6(Hazardous Substances Data)

Upstream product

• 175883-63-3 B-(3-chloro-4-methylphenyl)boronic acid 

Relevant articles and documents

Synthesis and SAR Studies of 1 H-Pyrrolo[2,3- b]pyridine-2-carboxamides as Phosphodiesterase 4B (PDE4B) Inhibitors

Herein we report the synthesis, SAR, and biological evaluation of a series of 1H-pyrrolo[2,3-b]pyridine-2-carboxamide derivatives as selective and potent PDE4B inhibitors. Compound 11h is a PDE4B preferring inhibitor and exhibited acceptable in vitro ADME and significantly inhibited TNF-α release from macrophages exposed to pro-inflammatory stimuli (i.e., lipopolysaccharide and the synthetic bacterial lipopeptide Pam3Cys). In addition, 11h was selective against a panel of CNS receptors and represents an excellent lead for further optimization and preclinical testing in the setting of CNS diseases.