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Upstream product

• 399-51-9 6-fluoro-1H-indole 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 1593-60-8 p-toluenesulfonylhydroxylamine 
• 1858-86-2 Ethyl p-toluenesulfinate 
• 98-59-9 p-toluenesulfonyl chloride 
• 106-45-6 para-thiocresol 

Relevant academic research and scientific papers

Preparation method of indole sulfide compound

The invention discloses a preparation method of an indole sulfide compound. The preparation method is conducted according to the following steps that a catalyst, an indole reactant, hydrazine hydrate,substituted phenyl sulfonyl chloride and a solvent are

Catalyst-free sulfenylation of indoles with sulfinic esters in ethanol

A novel catalyst-free method for the synthesis of structurally diverse indole thioethers in moderate to excellent yields has been developed. In this reaction, sulfinic esters serve as new sulfur electrophiles.

N-Hydroxy sulfonamides as new sulfenylating agents for the functionalization of aromatic compounds

An unprecedented use of N-hydroxy sulfonamides as sulfenylating agents has been established. In the presence of catalytic amounts of iodine and N-hydroxysuccinimide, N-hydroxy sulfonamides participated in sulfenylation with indoles, 7-azaindole, N-methyl pyrrole, and 2-naphthol to afford structurally diverse thioethers in moderate to excellent yields with very high regioselectivity.

Photocatalytic direct C-S bond formation: Facile access to 3-sulfenylindoles: Via metal-free C-3 sulfenylation of indoles with thiophenols

An efficient and convenient photocatalytic direct C-3 sulfenylation of indoles with thiophenols has been developed for the construction of 3-sulfenylations. This protocol employs thiophenols as the sulfenylating agents, inexpensive rose bengal as the photocatalyst, and shows mild conditions, readily available starting materials, high atom and step atom economy, and environmental advantages. The representative method provides a straightforward approach for C-S bond formation, and has potential applications in the chemical and pharmaceutical industries.

Preparation method for 3-sulfo-indoles compound

The invention relates to the technical field of organic synthesis and provides a preparation method for a 3-sulfo-indoles compound. The 3-sulfo-indoles compound is acquired through the substitution reaction of thiophenols compound and indoles compound under the photo-catalytic effect of photo-catalyst and organic solvent, wherein the photo-catalyst comprises one or more of eosin B, eosin Y and rose bengal. According to the preparation method provided by the invention, the reaction condition is mild, no alkali or oxidizing agent is required, no transition metal catalyst participates into the reaction, the adverse effect of the metal residue to the product performance is effectively avoided, the product performance is promoted, the product yield is increased to 70%, the multi-step synthesis of the reaction raw materials is not required and the technological process is simplified.

K2S2O8/arenesulfinate: An unprecedented thiolating system enabling selective sulfenylation of indoles under metal-free conditions

An unprecedented thiolating system K2S2O8/arenesulfinate is described for selective sulfenylation of indoles in CH3CN/H2O. This metal-free strategy enables a simple, efficient and environment-benign approach to the pharmaceutically important candidates, 3-arylthioindoles. Catalytically reactive halogen and aryl groups are well tolerated. This journal is

Copper-catalyzed aerobic oxidative N-S bond functionalization for C-S bond formation: Regio- and stereoselective synthesis of sulfones and thioethers

A regio- and stereoselective synthesis of sulfones and thioethers by means of CuI-catalyzed aerobic oxidative N-S bond cleavage of sulfonyl hydrazides, followed by cross-coupling reactions with alkenes and aromatic compounds to form the C-sp-2-S bond, is described herein. N2 and H2O are the byproducts of this transformation, thus offering an environmentally benign process with a wide range of potential applications in organic synthesis and medicinal chemistry. First cleave, then cross-couple: A direct Cu-catalyzed aerobic oxidative C-sp-2-H functionalization and C-S bond coupling reaction has been developed (see scheme). By slight modification of the additive, sulfonyl hydrazides could serve as sulfonation, sulfenation, or arylation reagents to undergo cross-coupling reactions with alkenes and (hetero)aromatic cycles, affording sulfones, thioethers, and biaryl compounds with high regio- and stereoselectivities (see scheme).